Fasting and Glucose-Stimulated Changes in Plasma Glucagon in Pancreatic Cancer: Potential Biomarkers for Detection?
Fasting and Glucose-Stimulated Changes in Plasma Glucagon in Pancreatic Cancer: Potential Biomarkers for Detection?
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DOI：
10.1097/mpa.0000000000001208
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发表时间：
2019-01
期刊：
影响因子：
2.9
通讯作者：
J. Stern;Y. Arriaga;Arjun Gupta;U. Verma;S. Karri;S. Syed;Leticia Khosama;J. Mansour;Jeffrey Meyer;P. Scherer;M. Beg
中科院分区：
文献类型：
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作者：
J. Stern;Y. Arriaga;Arjun Gupta;U. Verma;S. Karri;S. Syed;Leticia Khosama;J. Mansour;Jeffrey Meyer;P. Scherer;M. Beg
我们招募了14名患者，其中5名已知为T2 DM，9名为ND。对葡萄糖诱导的糖调节激素变化的方差分析显示，时间×糖尿病相互作用具有统计学意义。因此，单独分析ND和T2 DM患者的口服葡萄糖耐量数据。ND（n= 9）和T2 DM（n= 5）患者之间的基线BMI、空腹血糖、胰岛素、胰高血糖素、脂联素、C反应蛋白和CA 19-9无差异（P≥ 0.05）（表1）。
RESULTSWe enrolled 14 patients, of which 5 had known T2DM and 9 were ND. Analyses of variance for glucose-induced changes in glucoregulatory hormones revealed statistically significant time× diabetes interactions. Thus, oral glucose tolerance data were analyzed separately for ND and T2DM patients. Baseline BMI, fasting glucose, insulin, glucagon, adiponectin, C-reactive protein, and CA 19-9 did not differ between ND (n= 9) and T2DM (n= 5) patients (P≥ 0.05)(Table 1).