Age of entry to day nursery and allergy in later childhood
Age of entry to day nursery and allergy in later childhood
复制标题
DOI：
10.1016/s0140-6736(98)06329-6
复制
发表时间：
1999-02-06
期刊：
影响因子：
168.9
通讯作者：
Wichmann, HE
中科院分区：
文献类型：
--
作者：
Krämer, U;Heinrich, J;Wichmann, HE
背景儿童早期的感染可能会预防以后的过敏。如果这一假设是正确的，那么在家庭外早期接触儿童保育可以通过促进交叉感染来预防特应性疾病。我们调查了儿童谁参加幼儿园在年轻的时候有较低的过敏反应率和较少的过敏比儿童谁参加从一个较老的age.Methods在1992-93年进行的横断面研究中，我们检查了2471名儿童在三个年龄组（5-7，8-10，11-14岁）从城镇的Bitterfeld，Hettstedt，和泽布斯特在德国东部。这些孩子的父母回答了一份关于过敏和症状、日托出勤率和相关因素的问卷。敏感性进行了评估shin-prick测试和测量过敏原特异性IgE抗体在serum.Findings在669名儿童从小家庭（最多3人），特应性的患病率较高的儿童谁开始参加日间托儿所在年龄较大的比那些谁开始参加在一个年轻的年龄（P <0. 05）。与6-11个月时首次就诊的儿童相比，12-23个月时就诊的儿童皮肤点刺试验阳性的调整优势比为1.99（95%CI 1.08-3.66），24个月及以上就诊的儿童为2.72（1.37-5.40）。在1761名儿童从大家庭（超过3人），年龄进入日托没有影响atopy.Interpretation我们的研究结果雅阁的假设，早期感染可能会防止过敏在以后的生活。
Background Infections in early childhood may prevent allergies in later life. If this hypothesis is true, early exposure to childcare, outside the home would protect against atopy by promotion of cross infections. We investigated whether children who attend a nursery at a young age have a lower rate of atopy and fewer allergies than children who attend from an older age.Methods In a cross-sectional study carried out in 1992-93, we examined 2471 children in three age-groups (5-7, 8-10, and 11-14 years) from the towns of Bitterfeld, Hettstedt, and Zerbst in eastern Germany. The children's parents answered a questionnaire about allergies and symptoms, attendance at day care, and related factors. Sensitisation was assessed by shin-prick tests and measurement of allergen-specific IgE antibodies in serum.Findings In 669 children from small families (up to three people), the prevalance of atopy was higher among children who started to attend day nursery at an older age than in those who started to attend at a younger age (p < 0.05). Compared with children who first attended at age 6-11 months, the adjusted odds ratios for a positive skin-prick test were 1.99 (95% CI 1.08-3.66) for children who attended at age 12-23 months and 2.72 (1.37-5.40) for those who attended at age 24 months and older. In 1761 children from large families (more than three people), age of entry to day nursery had no effect on atopy.Interpretation Our findings accord with the hypothesis that early infection may protect against allergies in later life.