Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: The millennium genome project for hypertension
Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: The millennium genome project for hypertension
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DOI：
10.1291/hypres.31.203
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发表时间：
2008-02-01
影响因子：
5.4
通讯作者：
Miki, Tetsuro
中科院分区：
文献类型：
--
作者：
Kohara, Katsuhiko;Tabara, Yasuharu;Miki, Tetsuro
多候选基因方法不仅被用来研究候选基因，而且还被用来研究参与血压调节的候选通路。我们评估了307个基因的307个单核苷酸多态(SNPs)，并对758例患者和726名对照进行了关联研究。基因是从信号转导途径的编码成分中挑选出来的，包括受体、可溶性载体蛋白、结合蛋白、通道、酶和G蛋白，这些基因可能与血压调节有关。共检出38个SNP阳性(p<0.05)。
A multiple candidate-gene approach was used to investigate not only candidate genes, but also candidate pathways involved in the regulation of blood pressure. We evaluated 307 single nucleotide polymorphisms (SNPs) in 307 genes and performed an association study between 758 cases and 726 controls. Genes were selected from among those encoding components of signal transduction pathways, including receptors, soluble carrier proteins, binding proteins, channels, enzymes, and G-proteins, that are potentially related to blood pressure regulation. In total, 38 SNPs were positively (p