Application of magnetoencephalography in epilepsy patients with widespread spike or slow-wave activity
Application of magnetoencephalography in epilepsy patients with widespread spike or slow-wave activity
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DOI：
10.1111/j.1528-1167.2005.65504.x
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发表时间：
2005-08-01
期刊：
影响因子：
5.6
通讯作者：
Halgren, E
中科院分区：
文献类型：
--
作者：
Shiraishi, H;Ahlfors, SP;Halgren, E
目的：为了研究脑磁图（MEG）是否可以用来确定模式的大脑活动的基础广泛发作的癫痫patients.Methods的癫痫patients.Methods：我们研究了两个孩子有症状的定位相关的癫痫。例1有广泛的棘波脑电图与手术疤痕切除脑肿瘤;例2有半球慢波活动脑电图与感觉先兆。MEG是用204通道头盔形传感器阵列收集的。动态统计参数图（dSPM），以估计这些患者发作间期放电的皮层分布。结果：例1广泛棘波时，dSPM在棘波峰值时主要活动在左额叶手术疤痕附近，部分棘波峰值前在左颞叶检测到部分活动。在例2与半球慢波，最活跃的区域位于左顶叶，和额外的活动被视为在同侧颞叶和额叶的dSPM。源估计值与该患者的发作表现和发作间期单光子发射计算机断层扫描（SPECT）结果相关性良好。与ECDs的结果相比，病例1的ECDs不能表达左侧颞叶的先前活动，病例2的ECDs不能很好地模拟MEG数据。结论：我们认为，通过dSPM，MEG是有用的术前评估的病人，不仅局限性癫痫样活动，而且广泛的棘波或慢波，因为它不需要选择频道和时间点。
Purpose: To examine whether magnetoencephalography (MEG) can be used to determine patterns of brain activity underlying widespread paroxysms of epilepsy patients, thereby extending the applicability of MEG to a larger population of epilepsy patients.Methods: We studied two children with symptomatic localization-related epilepsy. Case 1 had widespread spikes in EEG with an operation scar from a resection of a brain tumor; Case 2 had hemispheric slow-wave activity in EEG with sensory auras. MEG was collected with a 204-channel helmet-shaped sensor array. Dynamic statistical parametric maps ( dSPMs) were constructed to estimate the cortical distribution of interictal discharges for these patients. Equivalent current dipoles (ECDs) also were calculated for comparison with the results of dSPM.Results: In case 1 with widespread spikes, dSPM presented the major activity at the vicinity of the operation scar in the left frontal lobe at the peak of the spikes, and some activities were detected in the left temporal lobe just before the peak in some spikes. In case 2 with hemispheric slow waves, the most active area was located in the left parietal lobe, and additional activity was seen at the ipsilateral temporal and frontal lobes in dSPM. The source estimates correlated well with the ictal manifestation and interictal single-photon emission computed tomography (SPECT) findings for this patient. In comparison with the results of ECDs, ECDs could not express a prior activity at the left temporal lobe in case 1 and did not model well the MEG data in case 2.Conclusions: We suggest that by means of dSPM, MEG is useful for presurgical evaluation of patients, not only with localized epileptiform activity, but also with widespread spikes or slow waves, because it requires no selections of channels and no time-point selection.