Clinical translation of nitrite therapy for cardiovascular diseases.
Clinical translation of nitrite therapy for cardiovascular diseases.
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DOI：
10.1016/j.niox.2009.11.001
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发表时间：
2010-02-15
期刊：
影响因子：
--
通讯作者：
Lefer DJ
中科院分区：
文献类型：
--
作者：
Calvert JW;Lefer DJ
阴离子亚硝酸盐是一氧化氮（NO）的氧化分解产物，传统上被视为生物系统中NO形成的诊断标志物。在这方面，亚硝酸盐一直被认为是一氧化氮代谢的惰性氧化产物。最近，这一观点已经改变，发现亚硝酸盐代表了血液和组织中一氧化氮的生理相关储存库，在病理条件下可以很容易地还原为一氧化氮。这引发了对亚硝酸盐生物学作用的新兴趣，并导致了大量研究其治疗潜力的工作。因此，亚硝酸盐疗法现已在许多疾病动物模型中显示出细胞保护作用。鉴于关于亚硝酸盐治疗的细胞保护作用的非常可靠的临床前数据，考虑亚硝酸盐治疗的临床转化是非常合乎逻辑的。本文将回顾一些临床前数据，并将讨论亚硝酸盐治疗作为治疗心血管疾病的潜在用途，包括：缺血再灌注损伤（即急性心肌梗死和中风）、高血压、血管生成，以及作为各种器官移植（即肝和肺）的辅助治疗。
The anion nitrite is an oxidative breakdown product of nitric oxide (NO) that has traditionally been viewed as a diagnostic marker of NO formation in biological systems. In this regard, nitrite has long been considered an inert oxidation product of NO metabolism. More recently, this view has changed with the discovery that nitrite represents a physiologically relevant storage reservoir of NO in blood and tissues that can readily be reduced to NO under pathological conditions. This has sparked a renewed interest in the biological role of nitrite and has led to an extensive amount of work investigating its therapeutic potential. As a result, nitrite therapy has now been shown to be cytoprotective in numerous animal models of disease. Given the very robust preclinical data regarding the cytoprotective effects of nitrite therapy it is very logical to consider the clinical translation of nitrite-based therapies. This article will review some of this preclinical data and will discuss the potential use of nitrite therapy as a therapeutic agent for the treatment of cardiovascular diseases including: ischemia-reperfusion injury (i.e. acute myocardial infarction and stroke), hypertension, angiogenesis, and as an adjunctive therapy for transplantation of various organs (i.e. liver and lung).
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