Regulation of claudins in blood-tissue barriers under physiological and pathological states.
Regulation of claudins in blood-tissue barriers under physiological and pathological states.
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DOI：
10.4161/tisb.24782
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发表时间：
2013-07-01
期刊：
影响因子：
3.1
通讯作者：
Fernandes R
中科院分区：
文献类型：
--
作者：
Gonçalves A;Ambrósio AF;Fernandes R
紧密连接蛋白是紧密连接的关键组成部分，形成上皮和内皮细胞的细胞旁屏障。在哺乳动物中，紧密连接蛋白是一个由 27 个基因组成的家族，编码四跨膜蛋白，在紧密连接的形成和完整性以及调节屏障功能中发挥着至关重要的作用。密蛋白亚型以组织和/或发育阶段依赖性方式表达。越来越多的证据表明，以神经炎症为特征的病理状态，如阿尔茨海默病、多发性硬化症、糖尿病性视网膜病变和早产儿视网膜病变有一个共同特征：屏障破坏。本综述旨在整合和总结紧密蛋白领域最相关和最新的工作，特别关注它们在血脑和血视网膜屏障中的作用，并描述它们在上述人类疾病中的调节。
Claudins are pivotal building blocks of tight junctions that form the paracellular barrier in epithelia and endothelia. In mammals, claudins are a 27-gene family that encodes tetraspan membrane proteins, playing a crucial role in the formation and integrity of tight junctions and regulate the barrier function. Claudin isoforms are expressed in a tissue- and/or developmental stage-dependent manner. A growing body of evidence indicates that pathological states characterized by neuroinflammation, such as Alzheimer disease, multiple sclerosis, diabetic retinopathy and retinopathy of prematurity share a common feature: the barrier breakdown. This review aims integrating and summarizing the most relevant and recent work developed in the field of claudins, with particular attention to their role in blood-brain and blood-retinal barriers, as well as describing their regulation in the aforementioned human diseases.