Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.
Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.
复制标题
PBPK建模中的应用概念：如何构建PBPK/PD模型。
DOI：
10.1002/psp4.12134
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发表时间：
2016-10
影响因子：
3.5
通讯作者：
Teutonico, D
中科院分区：
文献类型：
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作者：
Kuepfer, L;Niederalt, C;Wendl, T;Schlender, J-F;Willmann, S;Lippert, J;Block, M;Eissing, T;Teutonico, D
本教程的目的是介绍基于生理的药代动力学/药效学(PBPK/PD)建模的基本概念，并特别关注它们在典型的PBPK模型构建工作流程中的实际实施。为了说明建立PBPK模型的基本步骤，将构建环丙沙星的PBPK模型，并将其与药效学模型耦合以模拟环丙沙星的抗菌活性。
The aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow. To illustrate basic steps in PBPK model building, a PBPK model for ciprofloxacin will be constructed and coupled to a pharmacodynamic model to simulate the antibacterial activity of ciprofloxacin treatment.