Cardiac electrophysiological dynamics from the cellular level to the organ level.
Cardiac electrophysiological dynamics from the cellular level to the organ level.
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DOI：
10.4137/becb.s10960
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发表时间：
2013
影响因子：
2.8
通讯作者：
Clancy CE
中科院分区：
文献类型：
--
作者：
Sato D;Clancy CE
心脏交替描述了在恒定起搏频率下心室以强-弱-强-弱顺序收缩。临床上，交替表现为心电图上T波的交替，使个体易于心律失常和心脏性猝死。在这篇综述中，我们专注于交替的基本动力学机制，并显示如何交替在细胞水平的基础交替在组织和心电图。清楚了解交替基因的动力学机制对于制定有效的抗疟疾策略至关重要。
Cardiac alternans describes contraction of the ventricles in a strong-weak-strong-weak sequence at a constant pacing frequency. Clinically, alternans manifests as alternation of the T-wave on the ECG and predisposes individuals to arrhythmia and sudden cardiac death. In this review, we focus on the fundamental dynamical mechanisms of alternans and show how alternans at the cellular level underlies alternans in the tissue and on the ECG. A clear picture of dynamical mechanisms underlying alternans is important to allow development of effective anti-arrhythmic strategies.