Pharmaceutical process chemistry
Pharmaceutical process chemistry
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发表时间：
2011
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通讯作者：
塩入 孝之;K. Izawa;T. Konoike
中科院分区：
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作者：
塩入 孝之;K. Izawa;T. Konoike
从毫克到吨：合成与工艺研究在新药开发中的重要性基于酸碱组合化学-过氧化氢不对称氧化的动态盐催化剂的应用前景设计芳香化合物功能化的新方法C-H氧化副产物流线型合成催化加氢和转移加氢无C-C键酶-金属动力学拆分手性合成新工具中国有机药物合成的一些进展过程化学中的硼试剂氢氧化钠介导芳基化过程选择性还原的优良工具一种合成全氟化合物的全新方法全细胞生物催化剂在精细化学品制造中的应用第4部分：高效实用工艺的构建软软素B类似物、甲磺酸艾里布林工艺的合成研究蒽环类抗癌药物工艺的开发HIV整合酶抑制剂S-1360的开发PKC抑制剂JTT-010的高效合成KRP-103治疗尿失禁的实用工艺的开发RNA低聚物合成新方法的开发有用的工程技术爆炸反应过程研究有效设计的分子识别机制控制的新分辨技术新药和晶体多晶测量的发展和有效药物成分干燥机理的研究将化学与化学工程相匹配，以优化药物加工的设计和性能原料药的设计空间-凡德替尼的方法
PART 1: INTRODUCTORY REMARKS From Milligrams to Tons: The Importance of Synthesis & Process Research in the Development of New Drugs PART 2: FUTURE APPLICATIONS Design of Dynamic Salt Catalysts Based on Acid-Base Combination Chemistry Asymmetric Oxidation with Hydrogen Peroxide, an Effective and Versatile Oxidant New Methods for the Functionalization of Aromatic Compounds Streamlining Synthesis via C-H Oxidation Byproduct-Free C-C Bond Formation via Catalytic Hydrogenation and Transfer Hydrogenation Enzymo-Metallic Dynamic Kinetic Resolution as a New Tool for Chiral Synthesis Some Progress of Organic Synthesis of Pharmaceuticals in China PART 3: USEFUL SYNTHTIC TECHNOLOGIES Boron Reagents in Process Chemistry: Excellent Tools for Selective Reductions Commercialization of a Sodium Hydride Mediated Arylation Process An Entirely New Methodology for Synthesizing Perfluorinated Compounds Application of Whole-Cell Biocatalysts in the Manufacture of Fine Chemicals PART 4: CONSTRUCTION OF EFFICIENT PRACTICAL PROCESSES Synthetic Studies on the Halichondrin B Analog, Eribulin Mesylate Process Development of An Anthracycline Anticancer Drug Process Development of HIV Integrase Inhibitor S-1360 An Efficient Synthesis of the PKC Inhibitor JTT-010 Practical Process Development of KRP-103 for Treatment of Urinary Incontinence Development of a Novel Synthetic Method for RNA Oligomers PART 5: USEFUL ENGINEERING TECHNOLOGIES Process Research with Explosive Reactions Novel Resolution Technologies Controlled by Effectively Designed Molecular Recognition Mechanism Development on New Drug and Crystal Polymorph Measurements and Mechanism of Drying of Active Pharmaceutical Ingredients Matching Chemistry with Chemical Engineering for Optimum Design and Performance of Pharmaceutical Processing Design Space for Drug Substance - the Approach used for Vandetanib