Low molecular weight PTP-IL-4RA interaction in atopy predisposition
Low molecular weight PTP-IL-4RA interaction in atopy predisposition
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DOI：
10.1034/j.1398-9995.57.s72.4.x
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发表时间：
2002-01-01
期刊：
影响因子：
12.4
通讯作者：
Hopkin, JM
中科院分区：
文献类型：
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作者：
Bottini, N;Mao, XQ;Hopkin, JM
我们最近描述了低分子量蛋白酪氨酸磷酸酶（LMPTP） BC基因型对英国和意大利人群血清中高IgE水平的保护作用，该基因型与最高的总酶活性相关。在这里，我们检验了LMPTP在IL-4信号转导负调节中的作用的假设，检查白细胞介素-4受体α链（IL-4RA）遗传多态性和LMPTP多态性在英国人群高总IgE水平易感性中的遗传相互作用。我们发现LMPTP多态性与细胞内IL-4RA 551位Gln/Arg多态性之间存在显著的相互作用。我们的数据支持LMPTP和IL-4RA之间直接或间接的生化相互作用的假设，导致IL-4信号转导在联合基因型之间的不同调节。
We recently described a protective effect of the low molecular weight protein tyrosine phosphatase (LMPTP) BC genotype, associated with the highest total enzymatic activity, against high serum IgE levels both in the English and the Italian populations. Here we test the hypothesis of a role of LMPTP in the negative modulation of IL-4 signal transduction checking for genetic interaction between interleukin-4 receptor alpha chain (IL-4RA) genetic polymorphisms and LMPTP polymorphism in the predisposition to high total IgE levels in the English population. We find a significant interaction between LMPTP polymorphism and the intracellular Gln/Arg polymorphism in position 551 of IL-4RA. Our data support the hypothesis of a direct or indirect biochemical interaction between LMPTP and IL-4RA resulting in different modulation of IL-4 signal transduction among joint genotypes.