The transient appearance of small blastoid cells in the marrow after bone marrow transplantation.
The transient appearance of small blastoid cells in the marrow after bone marrow transplantation.
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骨髓移植后骨髓中短暂出现小胚细胞。
DOI：
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发表时间：
1991
影响因子：
3.5
通讯作者：
Fumio Kodama
中科院分区：
文献类型：
--
作者：
Shoichi Kobayashi;Kuniko Seki;Noriko Suwa;Chiyomi Koama;Toshiharu Yamamoto;Koudou Aiba;A. Maruta;Michio Matsuzaki;H. Fukawa;H. Kanamori;H. Harano;Hiroko Miyashita;Fumio Kodama
14 例接受同种异体或同基因骨髓移植的患者中，6 例移植后骨髓中短暂出现小胚细胞。这些患者中的大多数 (11) 患有白血病，但 3 名患者患有严重的再生障碍性贫血。细胞直径为8-18微米，细胞质稀少，细胞核致密，染色质光滑、均匀。它们通常具有明显的核裂隙。这些细胞占骨髓细胞总数的4.0-21.3%。它们不与过氧化物酶、α-萘基丁酸酯酶、萘酚 AS-D 氯乙酸酯酶或高碘酸希夫染色剂发生反应。免疫细胞化学分析显示，小胚细胞表达末端脱氧核苷酸转移酶、Ia 样、CD19 和 CD10 抗原以及细胞质 mu 重链，表明前体 B 细胞表型。 CD20抗原在这些细胞上不表达。数据表明，在B细胞谱系的分化中，细胞质mu可能早于CD20抗原表达。形态学、细胞化学和免疫表型特征并未将这些非肿瘤细胞与白血病淋巴细胞明显区分开来。与肿瘤细胞相比，小胚细胞的增加是一种短暂的、自限性的现象。这些细胞应该被认为是骨髓移植受者骨髓的常见成分。这些细胞在免疫恢复和造血中的意义和作用仍不确定。
Of 14 patients who underwent allogeneic or syngeneic bone marrow transplantation, 6 had a transient appearance of small blastoid cells in the bone marrow after transplantation. Most of these patients (11) had leukemia, although 3 had severe aplastic anemia. The cells were 8-18 micron in diameter and had scant cytoplasm and dense nuclei with smooth, homogeneous chromatin. They often had distinct nuclear clefts. These cells constituted 4.0-21.3% of the total number of bone marrow cells. They were not reactive with peroxidase, alpha-naphtyl butylate esterase, naphthol AS-D chloroacetate esterase, or periodic acid-Schiff stains. Immunocytochemical analysis revealed that the small blastoid cells expressed terminal deoxynucleotidyl transferase, Ia-like, CD19, and CD10 antigens and cytoplasmic mu heavy chains, indicating a precursor B-cell phenotype. CD20 antigen was not expressed on these cells. The data suggest that cytoplasmic mu may be expressed earlier than CD20 antigen in the differentiation of B-cell lineage. The morphologic, cytochemical, and immunophenotypic characteristics did not distinguish these nonneoplastic cells distinctly from leukemic lymphoblastic cells. The increase of small blastoid cells was a transient and self-limited phenomenon, in contrast to that of neoplastic blasts. These cells should be recognized as a common component of the bone marrow of marrow transplant recipients. The significance and role of these cells in immune recovery and hematopoiesis remain uncertain.
非T细胞急性淋巴细胞白血病的B细胞起源。
DOI：
10.1172/jci111428
发表时间：
1984
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Nadler,LM;Korsmeyer,SJ;Anderson,KC;Boyd,AW;Slaughenhoupt,B;Park,E;Jensen,J;Coral,F;Mayer,RJ;Sallan,SE
通讯作者：
Sallan,SE
B 细胞和 T 细胞谱系淋巴瘤表达常见急性淋巴细胞白血病抗原 (CALLA)。
影响因子：
20.3
作者：
Ritz,J;Nadler,LM;Bhan,AK;Notis-McConarty,J;Pesando,JM;Schlossman,SF
通讯作者：
Schlossman,SF
CALLA 阳性急性淋巴细胞白血病细胞和正常骨髓 CALLA 阳性 B 细胞前体之间表型的异同。
影响因子：
20.3
作者：
Ryan,DH;Chapple,CW;Kossover,SA;Sandberg,AA;Cohen,HJ
通讯作者：
Cohen,HJ