A novel diagnostic system for Doppler ultrasound of the peripheral arteries to detect the presence of thoracic aortic aneurysm
A novel diagnostic system for Doppler ultrasound of the peripheral arteries to detect the presence of thoracic aortic aneurysm
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DOI：
10.3233/bme-191047
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发表时间：
2019-01-01
影响因子：
1
通讯作者：
Saiki, Yoshikatsu
中科院分区：
文献类型：
--
作者：
Hayatsu, Yukihiro;Watanabe, Koyu;Saiki, Yoshikatsu
目的：我们的目的是开发一种新的超声系统，并探讨其可行性，无创检测胸主动脉瘤（TAA）在临床setting.METHODS：我们开发了一种新的超声系统，包括一个修改后的控制台和数据分析算法。该探索性研究包括100名因择期心血管手术住院的患者。入院后，使用新系统采集左颈动脉的动脉脉搏波形。基于这些数据，我们推断存在TAA的基础上动脉粘弹性和不稳定性，这是反映到时间平均轨迹的血管壁的变形所造成的血流扰动。同时，所有患者均接受计算机断层扫描作为术前筛查，以确认TAA的存在。计算了使用新型超声系统检测TAA的灵敏度和特异性。结果：37例患者的数据集不适合分析，因此被丢弃。根据计算机断层扫描结果，40例患者被归类为动脉瘤组，而23例被判定为没有主动脉瘤。另一方面，44名患者根据使用新系统获得的超声结果被诊断为TAA。超声系统的总体灵敏度和特异性分别为0.83和0.52，respectively.CONCLUSION：我们成功地开发了一种新的系统，用于无创，超声为基础的评价左颈动脉检测TAA。尽管需要改进探头和诊断算法，但作为社区级医疗保健计划的一部分，该器械具有用于大规模筛查以检测无症状TAA的潜在效用。
OBJECTIVE: We aimed to develop a novel ultrasound system and examine its feasibility for noninvasively detecting thoracic aortic aneurysm (TAA) in clinical settings.METHODS: We developed a novel ultrasound system consisting of a modified console and data analysis algorithm. The exploratory study included 100 patients hospitalized for elective cardiovascular surgery. After admission, the arterial pulse waveform at the left carotid artery was acquired using the novel system. Based on these data, we inferred the presence of TAA based on arterial viscoelasticity and instability, which are reflected into the time-averaged trajectory of deformation of the blood vessel wall caused by disturbance of blood flow. Meanwhile, all patients underwent computed tomography as preoperative screening to confirm the presence of TAA. The sensitivity and specificity of TAA detection using the novel ultrasound system were calculated.RESULTS: The datasets from 37 patients were not suitable for analysis and were thus discarded. Based on computed tomography findings, 40 patients were categorized into the aneurysm group while 23 were judged not to have and aortic aneurysm. On the other hand, 44 patients were diagnosed as having TAA based on ultrasound findings obtained using the novel system. The overall sensitivity and specificity of the ultrasound system were 0.83 and 0.52, respectively.CONCLUSION: We successfully developed a novel system for noninvasive, ultrasound-based evaluation of the left carotid artery to detect TAA. Although improvements to the probe and diagnostic algorithm are warranted, this device has potential utility for mass screening to detect asymptomatic TAA as part of community-level healthcare programs.