Neural correlates of interindividual differences in the subjective experience of pain
Neural correlates of interindividual differences in the subjective experience of pain
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DOI：
10.1073/pnas.1430684100
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发表时间：
2003-07-08
影响因子：
11.1
通讯作者：
Yen, YF
中科院分区：
文献类型：
--
作者：
Coghill, RC;McHaffie, JG;Yen, YF
有些人声称他们对疼痛非常敏感，而另一些人则说他们能很好地忍受疼痛。然而，很难确定这些主观报告是否反映了真实的个体间经验差异。使用心理物理评分来定义疼痛敏感性和功能性磁共振成像来评估大脑活动，我们发现高度敏感的个体比不敏感的个体表现出更频繁和更强烈的疼痛诱导的初级体感皮层、前扣带皮层和前额叶皮层的激活。通过识别主观差异的客观神经关联，这些发现证实了内省和主观报告作为第一人称体验交流手段的效用。
Some individuals claim that they are very sensitive to pain, whereas others say that they tolerate pain well. Yet, it is difficult to determine whether such subjective reports reflect true interindividual experiential differences. Using psychophysical ratings to define pain sensitivity and functional magnetic resonance imaging to assess brain activity, we found that highly sensitive individuals exhibited more frequent and more robust pain-induced activation of the primary somatosensory cortex, anterior cingulate cortex, and prefrontal cortex than did insensitive individuals. By identifying objective neural correlates of subjective differences, these findings validate the utility of introspection and subjective reporting as a means of communicating a first-person experience.