Enzymatic production and biological activities of chitosan oligosaccharides (COS): A review
Enzymatic production and biological activities of chitosan oligosaccharides (COS): A review
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DOI：
10.1016/j.carbpol.2005.08.012
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发表时间：
2005-12-14
影响因子：
11.2
通讯作者：
Rajapakse, N
中科院分区：
文献类型：
--
作者：
Kim, SK;Rajapakse, N
在过去的几十年里，许多研究人员将壳聚糖作为潜在的生物活性材料的来源。然而，壳聚糖在生物应用中具有几个缺点，包括在生理条件下的溶解性差。因此，部分水解壳聚糖-壳寡糖（COS）近年来引起了人们的兴趣。在过去的几年中，已经采取了几种技术方法来制备COS，并且由于安全和无毒的考虑，酶法制备方法引起了极大的兴趣。随着时间的推移，对酶法生产进行了新的改进，目前已发展为连续生产工艺。COS的许多生物活性，如抗微生物、抗癌、抗氧化和免疫刺激作用都依赖于其理化性质。本文综述了COS的不同酶法制备方法及其生物学活性。(c)2005爱思唯尔有限公司保留所有权利。
Many researchers have focused chitosan as a source of potential bioactive material during past few decades. However, chitosan has several drawbacks to be utilized in biological applications, including poor solubility under physiological conditions. Therefore, a new interest has recently been emerged on partially hydrolyzed chitosan, chitosan oligosaccharides (COS). During the resent past, several technological approaches have been taken to prepare COS and, enzymatic preparation methods captured a great interest due to safe and non-toxic concerns. With time, new improvements were introduced to enzymatic production and presently it has been developed to a continuous production process. Many of the biological activities reported for COS, such as antimicrobial, anticancer, antioxidant, and immunostimulant effects are depend on their physico-chemical properties. In this review, we have summarized different enzymatic preparation methods of COS and some of their reported biological activities. (c) 2005 Elsevier Ltd. All rights reserved.