Diffusional kurtosis and diffusion tensor imaging reveal different time-sensitive stroke-induced microstructural changes.
Diffusional kurtosis and diffusion tensor imaging reveal different time-sensitive stroke-induced microstructural changes.
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DOI：
10.1161/strokeaha.114.006782
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发表时间：
2015-02
期刊：
影响因子：
8.3
通讯作者：
Adkins DL
中科院分区：
文献类型：
--
作者：
Weber RA;Hui ES;Jensen JH;Nie X;Falangola MF;Helpern JA;Adkins DL
Diffusion magnetic resonance imaging (dMRI) is a promising, clinically feasible imaging technique commonly used to describe white matter changes following stroke. We investigated the sensitivity of dMRI to detect microstructural alterations in grey matter following sensorimotor cortex (SMC) stroke in adult male rats. The mean diffusivity (MD) and mean kurtosis (MK) of peri-lesion motor cortex (MC) was compared to measures in the contra-lesional forelimb area of SMC at 2h, 24h, 72h or 25d post-surgery. MD and MK were correlated to the surface densities of glia, dendrites and axons. Peri-lesional MK was increased at 72h and 25d post-stroke, while MD was no longer different from contra-lesion SMC at 24h post-stroke. There was a significant increase in the density of glial processes at 72h post-stroke in peri-lesional MC, which correlated with perilesional MD. These data support that MK and MD provide different but complimentary information regarding acute and chronic changes in peri-lesional cortex. Glia infiltration is associated with pseudonormalization of MD in the peri-lesion MC at 72h post-lesion; however, this association is absent 25d post-lesion. These data suggest that there are likely several different, time-specific microstructural changes underlying these two complimentary diffusion measures.
