Hot flushes, menstrual status, and hormone levels in a population-based sample of midlife women
Hot flushes, menstrual status, and hormone levels in a population-based sample of midlife women
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DOI：
10.1016/0029-7844(96)00196-2
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发表时间：
1996-09-01
影响因子：
7.2
通讯作者：
Burger, HG
中科院分区：
文献类型：
--
作者：
Guthrie, JR;Dennerstein, L;Burger, HG
目的：确定453名绝经前、围绝经期和绝经后妇女（48-59岁）潮热的发生频率，并探讨潮热报告与月经状况、血清雌二醇（E2）、抑制素和FSH水平、经前投诉史以及身体和生活方式因素的关系。方法：我们采用以人群为基础的样本。采访是在妇女的家中进行的。结果：潮热报告频率与月经状况相关（P < 0.001）。29%的闭经超过3个月和少于12个月的女性，37%的绝经后女性，62%的绝经后女性和15%的接受激素治疗的女性报告在过去两周内至少有一次潮热。每天至少有一次或更多次潮热的女性促卵泡激素水平更高（P < 0.001）；E2水平在每周经历一次或没有潮热的女性中较高（P < 0.001）。围绝经期出现潮热的妇女FSH水平较高（P = .03）。在绝经后的一组中，在经历潮热的妇女和没有经历潮热的妇女之间，研究的任何变量都没有显著差异。结论：末次月经后3个月或更长时间出现潮热最多。潮热的频率与促卵泡刺激素增加、E2减少和经前病史有关。
Objective: To determine the frequency of hot flashes in a population sample of 453 pre-, peri-, and postmenopausal women (aged 48-59 years), and to investigate the relationship of hot-flush reporting with menstrual status, serum levels of estradiol (E2), inhibin, and FSH, history of premenstrual complaints, and physical and life-style factors.Methods: We used a population-based sample. Interviews were conducted in the women's homes.Results: Frequency of hot-flush reporting was associated with menstrual status (P < .001). Twenty-nine percent of women who had more than 3 and less than 12 months of amenorrhea, and 37% of postmenopausal women, 62% of postmenopausal women, and 15% of women on hormone therapy reported having had at least one hot flush in the previous 2 weeks. Follicle-stimulating hormone levels were higher in women who experienced hot flushes at least once a day or more (P < .001); E2 levels were higher in women experiencing one or no hot flushes per week (P < .001). The women in the perimenopausal group who experienced hot flushes had higher FSH levels (P = .03). In the postmenopausal group, there was no significant difference with any of the variables studied between the women who were experiencing hot flushes and those who were not.Conclusion: Reporting of hot flushes is greatest 3 months or more after the final menstrual period. The frequency of hot flushes is associated with increasing FSH, decreasing E2, and a history of premenstrual complaints.