Diet and Risk of Incident Lung Cancer: A Large Prospective Cohort Study in UK Biobank
Diet and Risk of Incident Lung Cancer: A Large Prospective Cohort Study in UK Biobank
复制标题
饮食和肺癌发生风险：英国生物银行的一项大型前瞻性队列研究。
DOI：
10.1093/ajcn/nqab298
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发表时间：
2021-12-01
影响因子：
7.1
通讯作者：
Ma, Hongxia
中科院分区：
文献类型：
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作者：
Wei, Xiaoxia;Zhu, Chen;Ma, Hongxia
关于饮食和肺癌风险的流行病学证据仍然相互矛盾。我们试图系统地调查饮食因素是否与英国生物银行中肺癌发生的风险相关。方法本研究共纳入来自英国生物银行的416,588名参与者（54%为女性）。基于FFQs的基线数据，通过主成分分析确定了3种主要的饮食模式。采用Cox比例风险模型研究个体食物组和饮食模式与肺癌风险的关系。结果在中位随访7.13年期间，记录了1782例肺癌病例。关联分析显示，大量摄入红肉和加工肉与肺癌风险增加有关（红肉的HRper为50克/天：1.36；95%可信区间为1.13、1.65；加工肉的HRper为25克/天：1.30；95%可信区间为1.10、1.53）。然而，水果（每100克心率：0.90；95%可信区间：0.84,0.95）、蔬菜（每100克心率：0.89；95%可信区间：0.81,0.99）、早餐谷物（每50克心率：0.81；95%可信区间：0.74,0.89）和膳食纤维（每5克心率：0.76；95%可信区间：0.69,0.84）的摄入与肺癌风险呈负相关。对于饮食模式分析[四分位数(Q)比较]，高度坚持谨慎饮食模式（HRQ4与Q1比较：0.84;95% CI: 0.73, 0.96）与肺癌风险较低相关，而西方饮食模式（HRQ4与Q1比较：1.27;95% CI: 1.11, 1.46）与肺癌风险较高相关。结论：我们的研究表明，以高摄入水果、蔬菜、早餐谷物和膳食纤维为特征的饮食，以及低摄入红肉和加工肉类，与较低的肺癌风险有关。
Background Epidemiological evidence remains conflicting regarding diet and risk of lung cancer. Objectives We sought to systematically investigate whether dietary factors are associated with the risk of incident lung cancer in the UK Biobank. Methods A total of 416,588 participants (54% women) from the UK Biobank were included in the present study. Based on baseline data from FFQs, 3 main dietary patterns were identified by using principal component analysis. Cox proportional hazards models were used to investigate the association of individual food groups and dietary patterns with lung cancer risk. Results During a median follow-up of 7.13 y, 1782 incident lung cancer cases were documented. The association analysis showed high intake of red meat and processed meat was associated with an increased risk of lung cancer (HRper 50 g/d: 1.36; 95% CI: 1.13, 1.65 for red meat; HRper 25 g/d: 1.30; 95% CI: 1.10, 1.53 for processed meat). However, the consumption of fruits (HRper 100 g/d: 0.90; 95% CI: 0.84, 0.95), vegetables (HRper 100 g/d: 0.89; 95% CI: 0.81, 0.99), breakfast cereals (HRper 50 g/d: 0.81; 95% CI: 0.74, 0.89), and dietary fiber (HRper 5 g/d: 0.76; 95% CI: 0.69, 0.84) was inversely associated with the risk of lung cancer. For the dietary pattern analysis [quartile (Q) comparison], high adherence to the Prudent pattern (HRQ4 compared with Q1: 0.84; 95% CI: 0.73, 0.96) was associated with a lower risk of lung cancer, whereas the Western pattern (HRQ4 compared with Q1: 1.27; 95% CI: 1.11, 1.46) was associated with a higher risk of lung cancer. Conclusions Our study indicated that a diet characterized by high intake of fruits, vegetables, breakfast cereals, and dietary fiber, as well as low intake of red meat and processed meat, was associated with a lower risk of lung cancer.