A pilot home study of temporal variations of symptoms in chronic obstructive lung disease
A pilot home study of temporal variations of symptoms in chronic obstructive lung disease
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DOI：
10.1177/1099800407303501
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发表时间：
2007-07-01
影响因子：
2.5
通讯作者：
Smolensky, Michael H.
中科院分区：
文献类型：
--
作者：
McCarley, Cynthia;Hannernan, Sandra K.;Smolensky, Michael H.
这项初步研究的目的是描述慢性阻塞性肺病（COPD）患者的24小时呼吸困难、疲劳和呼气峰流速（PEFR）模式，并检查它们的相互关系。重复测量设计方案涉及10例中度至重度COPD患者，他们每天5次自我评估呼吸困难、疲劳和PEFR，持续8天。通过单余弦分析记录了40%的呼吸困难参与者、60%的疲劳参与者和60%的PEFR参与者的昼夜节律。8天，24小时平均呼吸困难和疲劳中度相关; 70%的样本显示显着的相关性。PEFR均值与呼吸困难和疲劳呈弱负相关。研究结果表明，在所有患者中，肺功能的昼夜节律可能与呼吸困难和疲劳的昼夜节律在时间上不相关，并且呼吸困难和疲劳的平均自我感知水平中度相关。
The purposes of this pilot study are to describe the 24-hr patterns of dyspnea, fatigue, and peak expiratory flow rate (PEFR) in patients with chronic obstructive pulmonary disease (COPD) and examine their interrelationships. The repeated-measures design protocol involved 10 patients with moderate to severe COPD who self-assessed dyspnea, fatigue, and PEFR five times a day for 8 days. Circadian rhythms were documented by single cosinor analysis in 40% of the participants for dyspnea, 60% for fatigue, and 60% for PEFR. The 8-day, 24-hr means of dyspnea and fatigue were moderately correlated; 70% of the sample displayed significant correlations. The means of PEFR and both dyspnea and fatigue were weakly negatively correlated. The findings suggest that circadian rhythm in lung function may not be temporally coupled with the circadian rhythm in dyspnea and fatigue in all patients and that the mean self-perceived levels of dyspnea and fatigue are moderately related.