PRIMARY PULMONARY NEOPLASMS IN BEAGLE DOGS EXPOSED TO AEROSOLS OF CE-144 IN FUSED-CLAY PARTICLES
PRIMARY PULMONARY NEOPLASMS IN BEAGLE DOGS EXPOSED TO AEROSOLS OF CE-144 IN FUSED-CLAY PARTICLES
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DOI：
10.1093/jnci/50.3.675
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发表时间：
1973-01-01
影响因子：
10.3
通讯作者：
REDMAN, HC
中科院分区：
文献类型：
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作者：
HAHN, FF;BENJAMIN, SA;REDMAN, HC
为了确定吸入144 Ce的影响，126只Beagle犬（包括15只对照）暴露于熔融粘土中的144 Ce或熔融粘土中的稳定铈的气溶胶。迄今为止，已有15只狗在吸入暴露后143-410天死于放射性肺炎和肺纤维化。吸入接触后750-1318天，原发性肺肿瘤导致5只犬死亡。计算得出的死亡前的肺辐射剂量为23，000 - 48，000拉德。5只犬均发现肺血管瘤，4只发现转移瘤。此外，1只犬患有肺纤维肉瘤，另1只患有细支气管肺泡癌，均转移至气管支气管淋巴结。在吸入144 Ce后186、193和410天，只有3只初始肺负荷相似的狗死亡，没有肺肿瘤。91只狗吸入~（144）Ce熔粘土后存活239-1565天，其中44只存活>750天，肺辐射剂量为2- 36，000拉德。
To determine the effects of inhaled144Ce, 126 Beagle dogs (including 15 controls) were exposed to aerosols of either144Ce in fused clay or stable cerium in fused clay. To date, 15 dogs have died 143–410 days after inhalation exposure from radiation pneumonitis and pulmonary fibrosis. Primary pulmonary neoplasms caused the deaths of 5 dogs 750–1318 days after inhalation exposure. Calculated pulmonary radiation doses until death ranged from 23,000–48,000 rads. Pulmonary hemangiosarcomas were found in all 5 dogs and metastasis in 4. In addition, 1 dog had a pulmonary fibrosarcoma and another had a bronchiolo-alveolar carcinoma, both of which metastasized to the tracheobronchial lymph nodes. Only 3 dogs with similar initial lung burdens of144Ce died without pulmonary neoplasms, at 186, 193, and 410 days after inhalation exposure. The 91 dogs exposed to144Ce-fused clay and all controls have survived 239–1565 days after inhalation exposure including 44 surviving >750 days, with pulmonary radiation doses from 2–36,000 rads.