Divergence between samples of chimpanzee and human DNA sequences is 5%, counting indels
Divergence between samples of chimpanzee and human DNA sequences is 5%, counting indels
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DOI：
10.1073/pnas.172510699
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发表时间：
2002-10-15
影响因子：
11.1
通讯作者：
Britten, RJ
中科院分区：
文献类型：
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作者：
Britten, RJ
五个黑猩猩细菌人工染色体 (BAC) 序列（在 GenBank 中描述）已与人类基因组序列的最佳匹配区域进行了比较，以测定 DNA 分歧的数量和类型。结论是我们与黑猩猩有 98.5% 的 DNA 序列相同的老观点可能是错误的。对于这个样本，更好的估计是 95% 的碱基对在黑猩猩和人类 DNA 之间完全相同。在这个 779 kb 的样本中，由于碱基替换而导致的差异为 1.4%，并且由于插入/缺失的存在而存在额外的 3.4% 差异。黑猩猩和人类序列中存在的比对缺口数量大致相等。正如 REPEATMASKER (http://ftp.genome.washington.edu/RM/RepeatMasker.html) 检测到的，它们在重复和非重复序列中同样出现。
Five chimpanzee bacterial artificial chromosome (BAC) sequences (described in GenBank) have been compared with the best matching regions of the human genome sequence to assay the amount and kind of DNA divergence. The conclusion is the old saw that we share 98.5% of our DNA sequence with chimpanzee is probably in error. For this sample, a better estimate would be that 95% of the base pairs are exactly shared between chimpanzee and human DNA. In this sample of 779 kb, the divergence due to base substitution is 1.4%, and there is an additional 3.4% difference due to the presence of indels. The gaps in alignment are present in about equal amounts in the chimp and human sequences. They occur equally in repeated and nonrepeated sequences, as detected by REPEATMASKER (http://ftp.genome.washington.edu/RM/ RepeatMasker.html).