Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM)
Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM)
复制标题
DOI：
10.4161/cbt.10.6.12537
复制
发表时间：
2010-09-15
影响因子：
3.6
通讯作者：
Karchin, Rachel
中科院分区：
文献类型：
--
作者：
Carter, Hannah;Samayoa, Josue;Karchin, Rachel
最近在24例胰腺癌中对2万多个基因进行了测序。我们将CHASM（体细胞突变的癌症特异性高通量注释）应用于在这24例癌症中发现的963个体细胞错义突变。CHASM识别出了假定的驱动突变（错误发现率……（此处句子不完整）
Over 20,000 genes were recently sequenced in a series of 24 pancreatic cancers. We applied CHASM (Cancer-specific High-throughput Annotation of Somatic Mutations) to 963 of the missense somatic missense mutations discovered in these 24 cancers. CHASM identified putative driver mutations (false discovery rate