Identifying miRNA-mRNA regulation network of major depressive disorder in ovarian cancer patients.
Identifying miRNA-mRNA regulation network of major depressive disorder in ovarian cancer patients.
复制标题
鉴定卵巢癌患者重度抑郁症的 miRNA-mRNA 调控网络。
DOI：
10.3892/ol.2018.9243
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发表时间：
2018-10
期刊：
影响因子：
2.9
通讯作者：
Shao Q
中科院分区：
文献类型：
--
作者：
Wu C;Zhao Y;Liu Y;Yang X;Yan M;Min Y;Pan Z;Qiu S;Xia S;Yu J;Yang P;Wan B;Shao Q
严重抑郁障碍(MDD)在卵巢癌患者中越来越常见，这使治疗过程复杂化。MicroRNA(MiRNA)-mRNA调控网络可能有助于阐明卵巢癌多药耐药的潜在机制。因此，使用GEO2R从GSE61741、GSE58105和GSE9116卵巢癌数据集中鉴定出差异表达的microRNAs(DEmiRs)和mRNAs(DEmRNAs)。然后使用TargetScan、microRNAorg、microT-CDS、miRDB和miRTarBase预测工具获得DEmiRs的靶基因。用David程序确定靶基因的KEGG通路，用Kaplan-Meier卵巢癌绘图仪确定严重抑郁障碍(MDD)的核心基因。从GSE61741和GSE58105中共获得5个DEmiRs(miR-23b-3p、miR-33b-3p、miR-1265、miR-933和miR-629-5p)。这些DEmiRs的靶基因在被认为是卵巢癌发生MDD的高风险途径中被丰富。从这些途径中筛选出11个风险基因作为卵巢癌MDD的miRNA-mRNAs网络的核心基因，最终确定了以下12对miRNA-mRNAs：miR-629-5p-FGF1、miR-629-5p-AKT3、miR-629-5p-MAGI2、miR-933-BDNF、miR-933-MEF2A、miR-23b-3p-TJP1、miR-23b-3p-JMJD1、miR-23b-3p-APAF1、miR-23b-3p-CAB39、miR-1265-CDKN1B、miR-33b-3p-CDKN1B和miR-33b-3p-F2R。这些结果可能为卵巢癌患者发生MDD的机制提供新的见解。
Major depression disorder (MDD) has become increasingly common in patients with ovarian cancer, which complicates the treatment course. The microRNA (miRNA)-mRNA regulation network may help elucidate the potential mechanism of MDD in ovarian cancer. The differentially expressed microRNAs (DEmiRs) and mRNAs (DEmRNAs) were therefore identified from the GSE61741, GSE58105 and GSE9116 ovarian cancer datasets using GEO2R. The target genes of the DEmiRs were then obtained using the TargetScan, microRNAorg, microT-CDS, miRDB and miRTarBase prediction tools. The DAVID program was used to identify the KEGG pathways of target genes, and the core genes of major depressive disorder (MDD) were identified using the Kaplan-Meier Plotter for ovarian cancer. A total of 5 DEmiRs (miR-23b-3p, miR-33b-3p, miR-1265, miR-933 and miR-629-5p) were obtained from GSE61741 and GSE58105. The target genes of these DEmiRs were enriched in pathways that were considered high risk for developing MDD in ovarian cancer. A total of 11 risk genes were selected from these pathways as the core genes in the miRNA-mRNA network of MDD in ovarian cancer, and eventually identified the following 12 miRNA-mRNAs pairs: miR-629-5p-FGF1, miR-629-5p-AKT3, miR-629-5p-MAGI2, miR-933-BDNF, miR-933-MEF2A, miR-23b-3p-TJP1, miR-23b-3p-JMJD1, miR-23b-3p-APAF1, miR-23b-3p-CAB39, miR-1265-CDKN1B, miR-33b-3p-CDKN1B, and miR-33b-3p-F2R. These results may provide novel insights into the mechanisms of developing MDD in ovarian cancer patients.
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