Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus
Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus
复制标题
DOI：
10.1101/cshperspect.a018903
复制
发表时间：
2016-01-01
影响因子：
7.2
通讯作者：
Schinder, Alejandro F.
中科院分区：
文献类型：
--
作者：
Toni, Nicolas;Schinder, Alejandro F.
成年海马会产生功能性齿状颗粒细胞(GC)，将谷氨酸释放到门区和氨角(CA)3区的靶细胞上，并接受谷氨酸和γ-氨基丁酸(GABA)能神经元输入，严格控制它们的放电活动。它们的兴奋性和抑制性输入的缓慢而有序的发展使它们与信息处理特别相关。尽管它们仍然不成熟，但新神经元通过传入活动被招募，并表现出更强的兴奋性，其输入和输出连接的活动依赖性可塑性增强，以及高突触生成率。一旦完全成熟，新的GC就会显示出发育过程中产生的神经元的所有特征。在这篇综述中，我们重点介绍了发育中的神经元如何重塑成年齿状回，并讨论了神经发生作为电路可塑性和功能机制的潜力的关键方面。
The adult hippocampus generates functional dentate granule cells (GCs) that release glutamate onto target cells in the hilus and cornus ammonis (CA) 3 region, and receive glutamatergic and gamma-aminobutyric acid (GABA) ergic inputs that tightly control their spiking activity. The slow and sequential development of their excitatory and inhibitory inputs makes them particularly relevant for information processing. Although they are still immature, new neurons are recruited by afferent activity and display increased excitability, enhanced activity-dependent plasticity of their input and output connections, and a high rate of synaptogenesis. Once fully mature, new GCs show all the hallmarks of neurons generated during development. In this review, we focus on how developing neurons remodel the adult dentate gyrus and discuss key aspects that illustrate the potential of neurogenesis as a mechanism for circuit plasticity and function.