Evaluation of glycogen loss in human liver transplants. Histochemical zonation of glycogen loss in cold ischemia and reperfusion.
Evaluation of glycogen loss in human liver transplants. Histochemical zonation of glycogen loss in cold ischemia and reperfusion.
复制标题
人肝移植中糖原损失的评估。
DOI：
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发表时间：
2003
影响因子：
1.6
通讯作者：
A. Chamlian
中科院分区：
文献类型：
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作者：
A. Cherid;N. Cherid;V. Chamlian;J. Hardwigsen;H. Nouhou;F. Dodero;L. Benkoel;Y. L. Le Treut;A. Chamlian
为了找到一个人肝移植的预后模型，我们评估了62例手术活检的糖原损失及其变化与冷缺血，再灌注，小叶分区和供体的年龄。应用单因素、多因素、判别分析和Logistic回归分析。在冷缺血和再灌注时，糖原有明显的小叶带状分布。在冷缺血期间，门静脉周围区和小叶周围区的平均损失分别为48%和74%。再灌注时，门静脉周围区为60%，小叶周围区为95%。在64%的移植物中观察到缺血时间小于10小时，在82%的移植物中观察到缺血时间为10小时或以上。再灌注时增加了90%，中心周围占优势。28岁以上供者的年龄是糖原丢失的加重因素。总之，在门静脉周围区，冷缺血和再灌注期间平均总糖原消耗约为54%。再灌注时下降90%，以中央周围为主。逻辑回归允许冷缺血和再灌注模型化。
To find a prognosis model of human liver transplant, we evaluate 62 surgical biopsies for the loss of glycogen and its variations in relation to cold ischemia, reperfusion, lobular zonation and donor's ages. We applied univariate, multivariate and discriminant analysis and logistic regression. There was a clear lobular zonation of glycogen during cold ischemia and at reperfusion. During cold ischemia, the mean loss was 48% in periportal zones and 74% in pericentrilobular zones. At reperfusion, it was in the range of 60% in periportal zones and 95% in pericentrilobular zones. It was observed in 64% of the grafts for an ischemia time less than 10 hr and in 82% of the grafts for an ischemia time of 10 hr or more. It was increased by 90% at reperfusion with pericentral predominance. Donors' age was an aggravating factor of glycogen loss beyond 28 years of age. In conclusion, in periportal zones, mean global glycogen depletion was about 54% during cold ischemia and reperfusion. It decreased by 90% at reperfusion with pericentral predominance. Logistic regression has allowed modelization of cold ischemia and reperfusion.