Melophlins P, Q, R, and S:: Four new tetramic acid derivatives, from two palauan marine sponges of the genus Melophlus
Melophlins P, Q, R, and S:: Four new tetramic acid derivatives, from two palauan marine sponges of the genus Melophlus
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DOI：
10.1248/cpb.54.852
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发表时间：
2006-06-01
影响因子：
1.7
通讯作者：
Namikoshi, Michio
中科院分区：
文献类型：
--
作者：
Xu, Jinzhong;Hasegawa, Masateru;Namikoshi, Michio
Four new tetramic acid derivatives, named melophlins P, Q, R, and S (1-4), were isolated from two marine sponges of the genus Melophlus collected at Palau, together with seven known melophlins A, D, E, G, H, I, and O. The structures of the new compounds were elucidated on the basis of their spectral data. The absolute stereochemistries at the tetramic acid moieties of the new compounds were determined as 1 : 1 mixtures (racemic) by ESI-LC/MS analysis of derivatives obtained by oxidation and hydrolysis of the respective parent compounds. Melophlins P-S (1-4) showed cytotoxicity against the murine leukemia cell line L1210 with IC50 values of 20.0, 10.5, 0.85, and 5.13 mu m, respectively.
