Expression of the class A macrophage scavenger receptor on specific subpopulations of murine dendritic cells limits their endotoxin response
Expression of the class A macrophage scavenger receptor on specific subpopulations of murine dendritic cells limits their endotoxin response
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DOI：
10.1002/eji.200535660
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发表时间：
2006-04-01
影响因子：
5.4
通讯作者：
Platt, N
中科院分区：
文献类型：
--
作者：
Becker, M;Cotena, A;Platt, N
树突状细胞（DC）在先天性和获得性免疫的界面处起作用，并且对特定刺激物独特地敏感。这些细胞上的模式识别受体（PRR）至关重要，因为它们能够识别并启动对保守的微生物相关分子特征的反应。除了Toll样受体（TLR），我们知道相对较少的具体分布的其他PRR之间的人口的DC。在这里，我们描述了小鼠A类巨噬细胞清道夫受体（SR-A）的表达，并表明它仅限于特定的骨髓来源和脾脏DC亚群。重要的是，我们证明，受体显着改变了DC的反应，内毒素。与迄今为止已经研究的其他PRR的活性相反，SR-A独特地限制了成熟反应; SR-A细胞显示出增强的CD 40表达和TNF-α产生。我们讨论了SR-A对DC生物学的潜在贡献，这种受体的已知的多种活动的背景下。
Dendritic cells (DC) function at the interface of innate and acquired immunity and are uniquely sensitive to specific stimuli. Pattern recognition receptors (PRR) on these cells are critically important because of their ability to recognise and initiate responses to conserved microbial-associated molecular signatures. With the exception of Toll-like receptors (TLR), we know relatively little about the specific distribution of other PRR amongst populations of DC. Here, we describe the expression of the murine class A macrophage scavenger receptor (SR-A) and show that it is restricted to specific subpopulations of bone marrow-derived and splenic DC. Importantly, we demonstrate that the receptor significantly alters the response of DC to endotoxin. In contrast to the activities of other PRR that have so far been examined, uniquely SR-A limits the maturation response; SR-A- cells display enhanced CD40 expression and TNF-alpha production. We discuss the potential contributions of SR-A to DC biology in the context of the known multiple activities of this receptor.