Evidence for dissociation between adrenarche and gonadarche: studies in patients with idiopathic precocious puberty, gonadal dysgenesis, isolated gonadotropin deficiency, and constitutionally delayed growth and adolescence.
Evidence for dissociation between adrenarche and gonadarche: studies in patients with idiopathic precocious puberty, gonadal dysgenesis, isolated gonadotropin deficiency, and constitutionally delayed growth and adolescence.
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肾上腺初现与性腺初现分离的证据：对特发性性早熟、性腺发育不全、孤立性促性腺激素缺乏以及体质性生长和青春期延迟患者的研究。
DOI：
10.1210/jcem-51-3-548
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
M. Grumbach
中科院分区：
文献类型：
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作者：
C. Sklar;S. Kaplan;M. Grumbach
为了检验这一假设，即肾上腺初显和下丘脑-垂体-性腺轴（性腺初显）的激活是独立的和分离的事件，由不同的机制控制，我们检查了肾上腺初显和性腺初显之间的关系，在各种临床疾病的性成熟患者。血浆硫酸脱氢表雄酮（DHEA-S）浓度被用作肾上腺雄激素分泌的激素标志物。26例特发性性早熟患者表现出两种不同的模式。17例6岁以前开始青春期的患者的DHEA-S平均血浆浓度与正常青春期前、肾上腺皮质激素分泌前的同性别、实足年龄（CA; 1-6岁）和骨龄（BA; 1-10岁）儿童的DHEA-S平均血浆浓度无差异。9例6 ~ 8岁性早熟患儿DHEA-S血浆浓度高于同龄青春期前儿童（86.4 ± 13.9 μ g/dl vs.10.0 ± 2.2 μg/dl; P < 0.004）。
To test the hypothesis that adrenarche and the activation of the hypothalamic-pituitary-gonadal axis (gonadarche) are independent and dissociated events, controlled by separate mechanisms, we examined the relationship between adrenarche and gonadarche in patients with a variety of clinical disorders of sexual maturation. The concentration of plasma dehydroepiandrosterone sulfate (DHEA-S) was used as a hormonal marker of adrenal androgen secretion. The 26 patients with idiopathic precocious puberty exhibited two distinct patterns. Seventeen patients with onset of puberty before 6 yr of age had a mean plasma concentration of DHEA-S which was not different from that of normal prepubertal, preadrenarchal children of the same sex, chronological age (CA; 1–6 yr), and bone age (BA; 1–10 yr). In contrast, 9 patients with onset of precocious puberty between 6 and 8 yr of age had a mean DHEA-S plasma concentration greater than that of agematched prepubertal children (86.4 ± 13.9 vs. 10.0 ± 2.2 μg/dl; P < 0.004) and...