Encoding of movement fragments in the motor cortex
Encoding of movement fragments in the motor cortex
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DOI：
10.1523/jneurosci.3570-06.2007
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发表时间：
2007-05-09
影响因子：
5.3
通讯作者：
Amit, Yali
中科院分区：
文献类型：
--
作者：
Hatsopoulos, Nicholas G.;Xu, Qingqing;Amit, Yali
先前的研究表明，复杂的运动可以通过对运动皮层的电刺激来引发。然而，大多数在运动皮层中的记录研究都研究了与时间无关的运动特征的编码，如方向、速度、位置或力。在这里，我们表明，单个运动皮层神经元编码时间演变的运动轨迹，而不仅仅是瞬时运动参数。我们使用简单的指数编码模型明确地描述了单个神经元的首选轨迹，并证明时间扩展轨迹不仅可以更准确地捕获运动皮质神经元的调谐，而且可以用于以更少的错误解码瞬时运动方向。这些发现表明，单个运动皮层神经元编码整个运动片段，这是时间上广泛的，可以是相当复杂的。
Previous studies have suggested that complex movements can be elicited by electrical stimulation of the motor cortex. Most recording studies in the motor cortex, however, have investigated the encoding of time-independent features of movement such as direction, velocity, position, or force. Here, we show that single motor cortical neurons encode temporally evolving movement trajectories and not simply instantaneous movement parameters. We explicitly characterize the preferred trajectories of individual neurons using a simple exponential encoding model and demonstrate that temporally extended trajectories not only capture the tuning of motor cortical neurons more accurately, but can be used to decode the instantaneous movement direction with less error. These findings suggest that single motor cortical neurons encode whole movement fragments, which are temporally extensive and can be quite complex.