RISK-FACTORS FOR THE DEVELOPMENT OF GLAUCOMATOUS VISUAL-FIELD LOSS IN OCULAR HYPERTENSION
RISK-FACTORS FOR THE DEVELOPMENT OF GLAUCOMATOUS VISUAL-FIELD LOSS IN OCULAR HYPERTENSION
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DOI：
10.1001/archopht.1994.01090170088028
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发表时间：
1994-05-01
影响因子：
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通讯作者：
GILBERT, D
中科院分区：
文献类型：
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作者：
QUIGLEY, HA;ENGER, C;GILBERT, D
目的：为了检测与未来青光眼视野丢失风险较高相关的高眼压患者的特征，方法：对647名双侧眼压高于21 mm Hg且最初视野检查结果正常的Goldmann视野计患者进行视盘、神经纤维层和视野的年度检查。68人在至少一只眼睛的两次连续Goldmann视野测试中出现视野缺陷，而其他579人保留正常视野。基线时中度或重度神经纤维层萎缩与7至8倍的视野丧失风险相关。与视野缺损发生率显著相关的属性包括面积比、较大的杯不对称性、椎间盘新月体的存在和较高的眼内压。发现与发病率不相关的特征是性别，种族，高血压，糖尿病，屈光不正，青光眼家族史，吸烟或饮酒史，和disc area.Conclusions：增加神经纤维层萎缩判断的半定量分级系统与高眼压症患者视野丧失的发展风险增加。视野丧失的发展与种族、近视、青光眼家族史和病史的关系比人们所认为的要复杂得多。
Objective: To detect characteristics of persons with ocular hypertension that are associated with a higher risk of future glaucomatous field loss.Methods: Annual examinations of the optic disc, nerve fiber layer, and visual field in 647 persons with bilateral intraocular pressure higher than 21 mm Hg and initially normal visual field test results with the Goldmann perimeter.Results: Sixty-eight persons developed a field defect on two consecutive Goldmann visual field tests in at least one eye, while 579 others retained normal fields. Moderate or severe nerve fiber layer atrophy at baseline was associated with a seven to eight times greater risk of development of visual field loss. Attributes that were significantly associated with the incidence of field loss inarea ratio, larger cup asymmetry, presence of disc crescent, and higher intraocular pressure. Characteristics found not to be associated with incidence were gender, race, hypertension, diabetes, refractive error, family history of glaucoma, smoking or alcohol drinking history, and disc area.Conclusions: Increasing nerve fiber layer atrophy judged by a semiquantitative grading system was associated with increasing risk of development of visual field loss among persons with ocular hypertension. The relationship of the development of field loss to race, myopia, family history of glaucoma, and medical history are more complex than has been presumed.