Twenty years of Prevention of Mother to Child HIV Transmission: research to implementation at a national referral hospital in Uganda.
Twenty years of Prevention of Mother to Child HIV Transmission: research to implementation at a national referral hospital in Uganda.
复制标题
预防母亲对儿童艾滋病毒传播的二十年：在乌干达一家国家转诊医院实施的研究。
DOI：
10.4314/ahs.v22i2.5s
复制
发表时间：
2022-08
影响因子：
1
通讯作者：
Musoke P
中科院分区：
文献类型：
--
作者：
Namara-Lugolobi E;Namukwaya Z;Owor M;Ouma J;Namale-Matovu J;Nakabiito C;Ndugwa C;Fowler MG;Musoke P
90%以上的儿童艾滋病毒新感染是通过母婴传播获得的。撒哈拉以南非洲预防母婴艾滋病毒传播（PMTCT）的研究为世卫组织提供了指导方针，使预防母婴传播规划得以在全球实施。描述马凯雷雷大学-约翰霍普金斯大学（MU-JHU）围产期艾滋病毒预防研究和穆拉戈国家转诊医院（MNRH）预防母婴传播计划的实施。总结1997-2016年在MU-JHU进行的围产期艾滋病毒预防研究。程序汇总数据提取和分析使用STATA 15。1999年，HIVNET 012研究表明，在分娩开始时给母亲和新生儿单剂量奈韦拉平（sdNVP）可使母婴传播减少近50%。2016年，PROMISE研究记录了妊娠和哺乳期间抗逆转录病毒治疗的安全性和有效性。MNRH的项目实施始于2000年。自2006年以来，接受艾滋病毒检测的人数从70%增加到99%。NVP是最初的抗逆转录病毒治疗方案，但到2012年，卫生部推荐了B+方案（三联疗法）。母婴传播率从2001年的16.9%降至2020年的2.3%。在MU-JHU进行的围产期艾滋病毒预防临床试验为世卫组织预防母婴传播指南提供了证据。MNRH项目评估表明，在过去二十年中，MTCT率显著下降。
Over 90% of new paediatric HIV infections are acquired through mother to child transmission. Prevention of mother to child HIV transmission (PMTCT) research in sub-Saharan Africa informed WHO guidelines which enabled implementation of PMTCT programs globally. To describe Makerere University-Johns Hopkins University (MU-JHU) perinatal HIV prevention research and implementation of the Mulago National Referral Hospital (MNRH) PMTCT program. Perinatal HIV prevention studies conducted at MU-JHU between 1997–2016 were summarized. Program aggregated data was extracted and analyzed using STATA 15. In 1999, the HIVNET 012 study demonstrated that single-dose nevirapine (sdNVP) to the mother at onset of labor and to her newborn, reduced MTCT by nearly 50%. In 2016, the PROMISE study documented the safety and efficacy of ART during pregnancy and breastfeeding period. Program implementation at MNRH started in 2000. Uptake of HIV testing increased from 70% to 99% from 2006 onwards. sd NVP was the initial ARV regimen but by 2012, MOH recommended Option B+(triple therapy). MTCT rates reduced from 16.9% in 2001 to 2.3% in 2020. Perinatal HIV prevention clinical trials conducted at MU-JHU provided evidence to inform WHO PMTCT guidelines. MNRH program evaluation demonstrated the significant decline in MTCT rates over the last two decades.
DOI：
10.1097/01.qai.0000435600.65845.31
发表时间：
2014-03-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Kaleebu P;Njai HF;Wang L;Jones N;Ssewanyana I;Richardson P;Kintu K;Emel L;Musoke P;Fowler MG;Ou SS;Jackson JB;Guay L;Andrew P;Baglyos L;Cao H;HPTN 027 protocol team
通讯作者：
HPTN 027 protocol team