Behavior of magnetic particles in hamster lungs: estimates of clearance and cytoplasmic motility.
Behavior of magnetic particles in hamster lungs: estimates of clearance and cytoplasmic motility.
复制标题
仓鼠肺中磁性颗粒的行为：清除率和细胞质运动的估计。
DOI：
10.1152/jappl.1983.55.4.1196
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
S. B. Bloom
中科院分区：
文献类型：
--
作者：
P. Gehr;J. Brain;I. Nemoto;S. B. Bloom
将悬浮在生理盐水中的亚铁磁性颗粒注入叙利亚金仓鼠的肺内。通过施加外部磁场使颗粒磁化并排列。在去除外部场时，颗粒从肺部产生回波磁场，该磁场由于颗粒的随机未对准而衰减（弛豫）。磁化和弛豫测量进行后立即滴注，然后重复在第一个24小时，最后在滴注后的几天到30天的间隔。每次外部磁化后立即产生的初始磁场的大小是肺中氧化铁含量的量度。其随时间降低，反映了颗粒清除率。在滴注后的第一个12小时内，松弛率急剧增加，在第5天和第30天之间缓慢下降。颗粒从细胞外到细胞内的位置变化以及细胞内从内质网到内质网的运动可能是导致观察到的弛豫速率随时间变化的原因。
Ferrimagnetic particles suspended in saline were instilled intratracheally into the lungs of Syrian golden hamsters. The particles were magnetized and aligned by applying an external magnetic field. Upon removal of the external field, the particles produced a remanent magnetic field from the lungs which decayed due to random misalignment of the particles (relaxation). Magnetization and relaxation measurements were performed immediately after instillation, then repeatedly during the first 24 h, and finally at intervals of several days up to 30 days after the instillation. The size of the initial remanent magnetic field immediately following each external magnetization is a measure of the amount of iron oxide in the lungs. It decreased with time, reflecting particle clearance. The rate of relaxation increased steeply during the first 12 h after the instillation and decreased slowly between the 5th and 30th day. Changes in the location of particles from extracellular to intracellular sites and movements from ectoplasmic to endoplasmic sites within cells may be responsible for the observed changes in relaxation rates with time.