Effects of isolation-rearing on voluntary consumption of ethanol, sucrose and saccharin solutions in Fawn Hooded and Wistar rats
Effects of isolation-rearing on voluntary consumption of ethanol, sucrose and saccharin solutions in Fawn Hooded and Wistar rats
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DOI：
10.1007/s002130050706
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发表时间：
1998-10-01
影响因子：
3.4
通讯作者：
Linnoila, M
中科院分区：
文献类型：
--
作者：
Hall, FS;Huang, S;Linnoila, M
这些实验检验了隔离饲养和压力影响享乐机制的假设。在实验 1 中，在家笼中监测 Fawn Hooded (FH) 和 Wistar 大鼠的自愿消耗乙醇和水。研究发现，FH 大鼠比 Wistar 大鼠消耗更多的低浓度乙醇，与饲养条件无关；而隔离饲养的大鼠则消耗更多的高浓度乙醇，与品系无关。在实验2中，发现隔离饲养的大鼠比社会饲养的大鼠消耗更多的蔗糖，与浓度无关。在实验3中，发现Fawn Hooded大鼠对低浓度糖精溶液更敏感，并且消耗较少的高浓度溶液，而隔离饲养发现增加了高浓度溶液的消耗。因此，享乐过程是由应变和饲养条件独立调节的，尽管隔离饲养的影响似乎在小鹿树林大鼠中加剧。
These experiments examined the hypothesis that isolation-rearing and strain influence hedonic mechanisms. In experiment 1, voluntary consumption of ethanol and water was monitored in the home cage of Fawn Hooded (FH) and Wistar rats. FH rats were found to consume more ethanol at low concentrations than Wistar rats, independent of rearing condition, and isolation-reared rats were found to consume more of high ethanol concentrations, independent of strain. In experiment 2, isolation-reared rats were found to consume more sucrose, independent of concentration, than socially reared rats. In experiment 3, Fawn Hooded rats were found to be more sensitive to low concentration solutions of saccharin, and to consume less of the high concentration solutions, while isolation-rearing was found to enhance consumption of high concentrations. Thus, hedonic processes are independently modulated by strain and rearing conditions, although the effects of isolation-rearing appear to be exacerbated in Fawn Wooded rats.