The prevalence of cystoid macular oedema on optical coherence tomography in retinitis pigmentosa patients without cystic changes on fundus examination
The prevalence of cystoid macular oedema on optical coherence tomography in retinitis pigmentosa patients without cystic changes on fundus examination
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DOI：
10.1038/eye.2008.110
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发表时间：
2009-04-01
期刊：
影响因子：
3.9
通讯作者：
Fishman, G. A.
中科院分区：
文献类型：
--
作者：
Hajali, M.;Fishman, G. A.
目的通过光学相干断层扫描（optical coherence tomography，OCT）检测视网膜色素变性（retinitis pigmentosa，RP）患者黄斑囊样水肿（cystoid macular oedema，CME）的发生率。所有患者均接受了完整的眼部检查，包括使用ETDRS（早期治疗糖尿病视网膜病变研究）图表的最佳矫正视力、眼内压测量、眼前节检查和详细的眼底检查。在63名患者中的50名患者中，使用径向切片仪方案进行傅立叶域OCT。63名患者中的另外13名在时域OCT单元上使用黄斑厚度协议进行扫描。CME的诊断定义的存在下，低反射性腔隙，边界清晰，至少有两个scans.Results的患者的平均年龄为36岁（范围9-71岁）。在63例患者检查，20例显示CME在至少一只眼睛（32%），而11例患者显示CME在双眼（18%）。结论我们的研究结果表明，相当数量的RP患者与CME，由OCT确定，可能不会显示囊性变化直接检眼镜或接触透镜生物显微镜。了解这些患者中CME的高频率可以用于识别那些可能适合当前或未来黄斑水肿治疗策略的患者，并可能影响未来将视敏度用作结局指标的治疗试验。临床研究
Purpose To determine the prevalence of cystoid macular oedema (CME) by optical coherence tomography (OCT) in retinitis pigmentosa (RP) patients with no evidence of cystic macular lesions on fundus examination.Methods We included 63 RP patients with no evidence of cystic-appearing macular changes on fundus examination. All patients underwent a complete ocular examination including best-corrected visual acuity using an ETDRS (Early Treatment Diabetic Retinopathy Study) chart, intraocular pressure measurement, anterior segment examination, and a detailed fundus examination. On 50 of the 63 patients, Fourier-domain OCT was performed using the radial slicer protocol. An additional 13 of the 63 patients were scanned using the macular thickness protocol on a time-domain OCT unit. The diagnosis of CME was defined by the presence of hyporeflective lacunae with well-defined boundaries on at least two of the scans.Results The mean age of patients included in the study was 36 years (range 9-71 years). Out of the 63 patients examined, 20 showed CME in at least one eye (32%), whereas 11 patients showed CME in both eyes (18%).Conclusions Our findings demonstrate that a substantial number of RP patients with CME, as determined by OCT, may not show cystic changes by direct ophthalmoscopy or contact lens biomicroscopy. Knowledge of the high frequency for CME in such patients can serve to identify those who may be amenable to current or future treatment strategies of their macular oedema and can potentially impact on future therapeutic trials where visual acuity is used as an outcome measure. CLINICAL STUDY