Prosthesis with neuromorphic multilayered e-dermis perceives touch and pain
Prosthesis with neuromorphic multilayered e-dermis perceives touch and pain
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DOI：
10.1126/scirobotics.aat3818
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发表时间：
2018-06-27
期刊：
影响因子：
25
通讯作者：
Thakor, Nitish V.
中科院分区：
文献类型：
--
作者：
Osborn, Luke E.;Dragomir, Andrei;Thakor, Nitish V.
人体是许多最先进的假肢设备和传感器的模板。对触觉和疼痛的感知是我们日常生活的基本组成部分，它传达了有关我们环境的有价值的信息，同时也提供了保护我们身体免受伤害的元素。假肢设计和控制机制的进步可以帮助截肢者恢复失去的功能，但往往缺乏有意义的触觉反馈或感知。通过经皮电神经刺激（TENS）与截肢者，我们发现并量化刺激参数，以引起无害（非疼痛）和有害（疼痛）的触觉感知幻手。躯体感觉区域的脑电图（EEG）活动证实了刺激期间幻手激活。我们发明了一种多层电子真皮（e-dermis），其特性基于机械感受器和伤害感受器的行为，为截肢者提供神经形态触觉信息。我们的生物启发电子真皮使假体及其用户能够通过产生受体样尖峰神经活动的神经形态界面感知从无害到有害触摸的连续光谱。在疼痛检测任务（PDT）中，我们展示了假肢和截肢者使用感觉反馈和疼痛反射反馈控制系统来区分非疼痛或疼痛触觉刺激的能力。在这项工作中，截肢者可以使用触觉和疼痛的感知来辨别物体的曲率，包括锐度。这项工作展示了创造一个更自然的感觉，跨越一系列的触觉刺激假肢手的可能性。
The human body is a template for many state-of-the-art prosthetic devices and sensors. Perceptions of touch and pain are fundamental components of our daily lives that convey valuable information about our environment while also providing an element of protection from damage to our bodies. Advances in prosthesis designs and control mechanisms can aid an amputee's ability to regain lost function but often lack meaningful tactile feedback or perception. Through transcutaneous electrical nerve stimulation (TENS) with an amputee, we discovered and quantified stimulation parameters to elicit innocuous (nonpainful) and noxious (painful) tactile perceptions in the phantom hand. Electroencephalography (EEG) activity in somatosensory regions confirms phantom hand activation during stimulation. We invented a multilayered electronic dermis (e-dermis) with properties based on the behavior of mechanoreceptors and nociceptors to provide neuromorphic tactile information to an amputee. Our biologically inspired e-dermis enables a prosthesis and its user to perceive a continuous spectrum from innocuous to noxious touch through a neuromorphic interface that produces receptor-like spiking neural activity. In a pain detection task (PDT), we show the ability of the prosthesis and amputee to differentiate nonpainful or painful tactile stimuli using sensory feedback and a pain reflex feedback control system. In this work, an amputee can use perceptions of touch and pain to discriminate object curvature, including sharpness. This work demonstrates possibilities for creating a more natural sensation spanning a range of tactile stimuli for prosthetic hands.