An 800 nm driven NaErF4@NaLuF4 upconversion platform for multimodality imaging and photodynamic therapy
An 800 nm driven NaErF4@NaLuF4 upconversion platform for multimodality imaging and photodynamic therapy
复制标题
用于多模态成像和光动力治疗的 800 nm 驱动 NaErF4@NaLuF4 上转换平台
DOI：
10.1039/c8nr00446c
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发表时间：
2018-07-14
期刊：
影响因子：
6.7
通讯作者：
Kong, Xianggui
中科院分区：
文献类型：
--
作者：
Li, Qiqing;Li, Xiaodan;Kong, Xianggui
基于镧系元素掺杂的上转换纳米颗粒（UCNPs）的多模态成像引导治疗已成为癌症治疗诊断学的趋势。然而，光动力学治疗（PDT）中980 nm激发的过热效应以及在单个粒子内优化多模态成像集成的困难仍然是挑战。在此，800 nm驱动的NaErF4@NaLuF4 UCNPs已被探索用于优化多模态成像和近红外（NIR）触发的PDT。我们的研究结果证实，最佳的壳层厚度近似为5 nm，可以很好地平衡上转换发光的增强和从Er 3+到光敏剂的能量转移效率的衰减，以实现在800 nm激发下用于PDT的单线态氧（O-1（2））的有效产生。此外，所获得的NaErF4@NaLuF4 UCNP显示出有效的和适用的性能，用于上转换发光（UCL）成像、X射线计算机断层扫描（CT）和高场T-2磁共振成像（MRI）。这种纳米材料可以作为一种优秀的治疗诊断剂，用于多模态成像和图像引导治疗。
Multimodality imaging-guided therapy based on lanthanide-doped upconversion nanoparticles (UCNPs) has become a trend in cancer theranostics. However, the overheating effect of 980 nm excitation in photodynamic therapy (PDT) and the difficulties in optimizing multimodality imaging integration within a single particle are still challenges. Herein, 800 nm driven NaErF4@NaLuF4 UCNPs have been explored for optimized multimodality imaging and near-infrared (NIR) triggered PDT. Our results confirmed that the optimal similar to 5 nm shell thickness can well balance the enhancement of upconversion luminescence and the attenuation of energy transfer efficiency from Er3+ towards a photosensitizer, to achieve efficient production of singlet oxygen (O-1(2)) for PDT under 800 nm excitation. Furthermore, the as-obtained NaErF4@NaLuF4 UCNPs showed effective and applicable performance for upconversion luminescence (UCL) imaging, X-ray computed tomography (CT), and high-field T-2 magnetic resonance imaging (MRI). This nanomaterial can serve as an excellent theranostic agent for multimodality imaging and image-guided therapy.