Targeting monocyte recruitment in CNS autoimmune disease
Targeting monocyte recruitment in CNS autoimmune disease
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DOI：
10.1006/clim.2001.5167
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发表时间：
2002-05-01
影响因子：
8.6
通讯作者：
Weiner, HL
中科院分区：
文献类型：
--
作者：
Izikson, L;Klein, RS;Weiner, HL
单核细胞和巨噬细胞在许多自身免疫性炎症疾病中起致病作用。最近对多发性硬化症动物模型——实验性自身免疫性脑脊髓炎（EAE）的研究发现了趋化因子介导的单核细胞归巢中枢神经系统（CNS）的关键机制。在这里，我们总结了目前EAE的研究结果，发展了靶向趋化因子轴以治疗中枢神经系统炎症性疾病的基本原理，并回顾了目前可用的抑制单核细胞运输到中枢神经系统的分子特异性治疗方法。(C) 2002 Elsevier Science （USA）。
Monocytes and macrophages play a pathogenic role in a number of autoimmune inflammatory diseases. Recent studies in experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis, have identified a critical chemokine-mediated mechanism of monocyte homing to the central nervous system (CNS). Here, we summarize the current findings in EAE, develop a rationale for targeting the chemokine axis in order to treat CNS inflammatory disease, and review currently available molecule-specific therapeutics that inhibit monocyte trafficking to the CNS. (C) 2002 Elsevier Science (USA).