Influence of Phasic Muscle Contraction upon the Quadripulse Stimulation (QPS) Aftereffects.
Influence of Phasic Muscle Contraction upon the Quadripulse Stimulation (QPS) Aftereffects.
复制标题
阶段性肌肉收缩对四脉冲刺激 (QPS) 后遗症的影响。
DOI：
10.1016/j.clinph.2015.10.063
复制
发表时间：
2016
影响因子：
4.7
通讯作者：
Ugawa Y
中科院分区：
文献类型：
--
作者：
Kadowaki S;Enomoto H;Murakami T;Nakatani-Enomoto S;Kobayashi S;Ugawa Y
目的目标肌肉的收缩影响重复经颅磁刺激（rTMS）的后遗症。本文的目的是探讨手部随意运动是否影响四脉冲刺激(QPS)对手部运动区的后遗症。方法13名健康志愿者参与本研究。对右侧第一背侧骨间肌 (FDI) 的运动热点进行 QPS-5 或 QPS-50 干预后，受试者执行自愿运动任务（以 1 Hz 的频率打开-关闭右手运动 1 分钟）。我们比较了有和无随意运动条件下MEP大小的时间进程。结果当受试者在QPS后立即移动他们的手时，QPS-5和QPS-50后遗症都被消除。然而，如果他们在QPS后20分钟移动双手，则长期后效应得以保留。结论干预后施加的自愿手部运动会影响QPS后效，但影响的大小取决于QPS和自愿运动之间的延迟。意义在可塑性诱导实验中，我们应该时刻注意这样一个事实，包括目标肌肉在内的自愿运动会严重影响QPS诱导的长期效应。
ObjectiveContractions of the target muscle influence the aftereffects of repetitive transcranial magnetic stimulation (rTMS). The aim of this paper is to investigate whether or not voluntary hand movement influences the aftereffects of quadripulse stimulation (QPS) on the hand motor area.MethodsThirteen healthy volunteers participated in this study. After QPS-5 or QPS-50 intervention over the motor hot spot for the right first dorsal interosseous muscle (FDI), the subjects performed voluntary motor tasks (opening–closing right hand movements at 1 Hz for 1 min). We compared the time courses of MEP size between the conditions with and without voluntary movement.ResultsWhen the subjects moved their hands immediately after QPS, both QPS-5 and QPS-50 aftereffects were abolished. However, if they moved their hands at 20 min after QPS, the long-term aftereffects were preserved.ConclusionsVoluntary hand movement applied after intervention influences QPS aftereffects, but the magnitude of the influence depends on the delay between QPS and the voluntary movement.SignificanceIn the plasticity induction experiments, we should always be mindful of the fact that voluntary movement, including the target muscle, seriously influences the induced long-term effects of QPS.