Obesity, overweight and patterns of osteoarthritis:: The Ulm Osteoarthritis Study
Obesity, overweight and patterns of osteoarthritis:: The Ulm Osteoarthritis Study
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DOI：
10.1016/s0895-4356(99)00162-6
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发表时间：
2000-03-01
影响因子：
7.2
通讯作者：
Brenner, H
中科院分区：
文献类型：
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作者：
Stürmer, T;Günther, KP;Brenner, H
本研究的目的是评估肥胖与膝关节、髋关节和手部骨关节炎（OA）之间的关系。我们研究了809例因OA而行膝关节或髋关节置换术的患者的OA模式。根据对侧关节或不同手指关节的影像学表现，骨性关节炎患者分为双侧骨性关节炎或全身性骨性关节炎，根据体重指数（BMI）分为体重正常、超重或肥胖。用多变量logistic回归估计相对权重和OA模式的优势比（OR）和95%置信区间（CI）。85%的参与者患有双侧OA， 26%患有全身性OA， 31%患有肥胖。肥胖（BMI大于或等于30 kg/m）；Or = 8.1；95% CT: 2.4-28)和超重（BMI大于或等于25kg /m）；Or = 5.9；95% CI: 2.0-18)与双侧膝关节OA密切相关。肥胖与双侧髋关节OA （OR = 0.7; 95% CI: 0.3-1.7）和广泛性OA （OR = 1.1; 95% CI: 0.6-21）之间没有关联。肥胖似乎是OA的机械风险因素，而不是系统性风险因素，膝关节尤其容易受到影响。(C) 2000 Elsevier Science Inc.；版权所有。
The objective of this study was to assess the association between obesity and osteoarthritis (OA) of the knee, hip, and hand. OA patterns were studied in 809 patients with knee or hip joint replacement due to OA. Patients with OA were categorized as having bilateral or generalized OA according to the presence of radiographic OA in the contralateral joint or different finger joints, and as normal weight, overweight, or obese according to their body mass index (BMI). Odds ratios (OR) and 95% confidence intervals (CI) for relative weight and OA patterns were estimated with multivariable logistic regression. Eighty-five percent of participants had bilateral OA, 26% had generalized OA, and 31% were obese. Obesity (BMI greater than or equal to 30 kg/m(2); OR = 8.1; 95% CT: 2.4-28) and overweight (BMI greater than or equal to 25 kg/m(2); OR = 5.9; 95% CI: 2.0-18) were strongly associated with bilateral knee OA. No association between obesity and bilateral hip OA (OR = 0.7; 95% CI: 0.3-1.7) nor generalized OA (OR = 1.1; 95% CI: 0.6-21) was observed. Obesity seems to be a mechanical rather than a systemic risk factor fur OA with the knee joint being especially susceptible. (C) 2000 Elsevier Science Inc. All rights reserved.