Stable bioenergetic status despite substantial changes in blood flow and tissue oxygenation in a rat tumour.
Stable bioenergetic status despite substantial changes in blood flow and tissue oxygenation in a rat tumour.
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DOI：
10.1038/bjc.1994.7
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发表时间：
1994-01
影响因子：
8.8
通讯作者：
Engel, T
中科院分区：
文献类型：
--
作者：
Vaupel, P;Kelleher, D K;Engel, T
关于S.C.的实验。对大鼠肿瘤(DS肉瘤)进行研究，以确定肿瘤血流的慢性或急性变化是否必然导致组织氧合和生物能量状态的变化，因为血流通常被认为是肿瘤生物能量状态的最终决定因素。基于这项研究，有明确的实验证据表明，与生长相关的或急性的(以下静脉注射)。给予肿瘤坏死因子α)可使肿瘤血流量减少，同时伴有组织氧合的平行改变。相反，只要流量值不低于0.4-0.5mlg-1min-1，并且葡萄糖作为主要底物可以从扩大的间质中招募，肿瘤能量状态就保持稳定。灌注率似乎只在低血流肿瘤或低血流组织区域起着决定能量状态的重要作用。
Experiments on s.c. rat tumours (DS sarcoma) were performed to determine whether chronic or acute changes in tumour perfusion necessarily lead to changes in tissue oxygenation and bioenergetic status since, as a rule, blood flow is thought to be the ultimate determinant of the tumour bioenergetic status. Based on this study, there is clear experimental evidence that growth-related or acute (following i.v. administration of tumour necrosis factor alpha) decreases in tumour blood flow are accompanied by parallel alterations in tissue oxygenation. In contrast, tumour energy status remains stable as long as flow values do not fall below 0.4-0.5 ml g-1 min-1, and provided that glucose as the main substrate can be recruited from the enlarged interstitial compartment. Perfusion rate seems to play a paramount role in determining energy status only in low-flow tumours or low-flow tissue areas.