Insulin Resistance: the Link Between Obesity and Cardiovascular Disease
Insulin Resistance: the Link Between Obesity and Cardiovascular Disease
复制标题
DOI：
10.1016/j.ecl.2008.06.005
复制
发表时间：
2008-09-01
影响因子：
4.5
通讯作者：
Reaven, Gerald M.
中科院分区：
文献类型：
--
作者：
Reaven, Gerald M.
胰岛素介导的葡萄糖处置在表面健康的个体中变化至少六倍。身体健康水平下降对胰岛素敏感性的不利影响与过度肥胖的不利影响相当，每种影响约占胰岛素作用变异性的25%。胰岛素敏感性的丧失解释了为什么肥胖者更容易患心血管疾病，但并非所有超重/肥胖者都有胰岛素抵抗。在临床水平上，重要的是要确定那些超重的人谁也胰岛素抵抗，并开始在这个亚组最密集的治疗努力。最后，似乎整体肥胖的不利影响，如体重指数估计，是腹部肥胖，如腰围量化。
Insulin-mediated glucose disposal varies at least sixfold in apparently healthy individuals. The adverse effect of decreases in the level of physical fitness on insulin sensitivity is comparable to the untoward impact of excess adiposity, with each accounting for approximately 25% of the variability of insulin action. It is the loss of insulin sensitivity that explains why obese individuals are more likely to develop cardiovascular disease, but not all overweight/obese individuals are insulin resistant. At a clinical level, it is important to identify those overweight individuals who are also insulin resistant and to initiate the most intensive therapeutic effort in this subgroup. Finally, it appears that the adverse impact of overall obesity, as estimated by body mass index, is comparable to that of abdominal obesity, as quantified by waist circumference.