Lack of functional estrogen receptor β influences anxiety behavior and serotonin content in female mice
Lack of functional estrogen receptor β influences anxiety behavior and serotonin content in female mice
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DOI：
10.1016/j.physbeh.2004.11.002
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发表时间：
2005-01-31
影响因子：
2.9
通讯作者：
Rissman, EF
中科院分区：
文献类型：
--
作者：
Imwalle, DB;Gustafsson, JÅ;Rissman, EF
雌激素与女性焦虑的调节有关。在这里，我们报告了在雌性雌激素受体β（ER β）敲除（ER β KO）和野生型（WT）小鼠中进行的焦虑测试结果。卵巢切除（OVX）小鼠长期雌二醇（E2）替代治疗没有表现出不同的高架十字迷宫相比，OVX小鼠没有经历激素替代。然而，注意到基因型差异; WT雌性比ERbetaKO同窝仔更可能探索迷宫开放臂的远端部分。此外，ER KO雌性小鼠的几个脑区（包括：终纹床核、视前区和海马）的5-羟色胺（5-HT）含量显著低于WT同窝小鼠。中缝背核也有类似的变化趋势。与WT动物的脑相比，ER KO小鼠尾壳核内的多巴胺含量降低。因此，在缺乏功能性ER β的情况下，无论血浆中是否存在循环E2，雌性小鼠在几个脑区表现出焦虑增强和5-HT或多巴胺浓度降低。我们假设雌激素受体β在发育过程中调节雌激素对雌性小鼠大脑中焦虑和儿茶酚胺浓度的影响是必需的。(C)2004年爱思唯尔公司All rights reserved.
Estrogen has been linked to the modulation of anxiety in females. Here we report results of anxiety tests conducted in female estrogen receptor beta (ERbeta) knockout (ERbetaKO) and wild-type (WT) mice. Ovariectomized (OVX) mice treated with chronic estradiol (E2) replacement did not behave differently on the elevated plus-maze when compared with OVX mice that did not experience hormone replacement. However, a genotype difference was noted; WT females were more likely to explore the distal portion of the open arm of the maze than ERbetaKO littermates. In addition, ER KO female mice had significantly lower serotonin (5-HT) content than WT littermates in several brain regions including: the bed nucleus of the stria terminalis, preoptic area, and hippocampus. A similar trend was noted in the dorsal raphe nucleus. Dopamine content was reduced within the caudate putamen in ER KO mice as compared to brains from WT animals. Thus, in the absence of functional ERbeta, regardless of the presence or absence of circulating E2 in plasma, female mice exhibited enhanced anxiety and decreased concentrations of 5-HT or dopamine in several brain regions. We hypothesize that ERbeta is required during development to modulate the effects of estrogen on anxiety and catecholamine concentrations in female mouse brains. (C) 2004 Elsevier Inc. All rights reserved.