Norwalk virus vaccines: Challenges and progress
Norwalk virus vaccines: Challenges and progress
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DOI：
10.1086/315579
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发表时间：
2000-05-01
影响因子：
6.4
通讯作者：
Graham, DY
中科院分区：
文献类型：
--
作者：
Estes, MK;Ball, JM;Graham, DY
人类杯状病毒（HumanCaliciviruses，HuCVs）是世界范围内急性非细菌性胃肠炎暴发的主要原因。越来越多的人认识到这些病毒作为引起食源性和水媒疾病的人类病原体的临床意义，这表明有效的疫苗将是有用的。本文综述了目前存在的挑战，为HuCV的疫苗的发展，以及候选疫苗的发展状况。HuCV是表现出对人胃肠道感染的有限向性的病毒，并且可以获得感染和疾病的志愿者模型。作为具有有限宿主范围的病原体，HuCV是理解介导和调节人类胃肠道病毒感染和粘膜免疫的机制的极好模型。
Human caliciviruses (HuCVs) are the major cause of outbreaks of acute nonbacterial gastroenteritis throughout the world. An increasing recognition of the clinical significance of these viruses as human pathogens causing foodborne and waterborne disease indicates that an effective vaccine would be useful. This article reviews the current challenges that exist for the development of a vaccine for the HuCVs as well as the status of development of a candidate vaccine. HuCVs are viruses that exhibit a restricted tropism for infection of the gastrointestinal tract of humans, and a volunteer model of infection and disease is available. As pathogens with a restricted host range, the HuCVs are excellent models for understanding the mechanisms that mediate and regulate viral infection of the gastrointestinal tract and mucosal immunity in humans.