LINKERS: a simulation programming system for generating populations with genetic structure.
LINKERS: a simulation programming system for generating populations with genetic structure.
复制标题
LINKERS：用于生成具有遗传结构的群体的模拟编程系统。
DOI：
10.1016/0010-4825(90)90036-o
复制
发表时间：
1990
影响因子：
7.7
通讯作者：
Rich,SS
中科院分区：
文献类型：
--
作者：
Yang,JJ;Ackerman,E;Rich,SS
介绍了蒙特卡罗仿真系统的主要特点。LINKERS，它产生符合一个位点和两个位点遗传模型的核心家族数据。软件工程技术有助于为基因确定的研究创造一个用户友好的环境。LINKERS的39个代码模块使用VAXset进行维护和优化。在VAX/VMS工作站环境中，LINKERS在1分钟内生成10,000个家庭的有用人口。给出了一个例子来说明链接器的使用。生成的数据使用分离程序POINTER进行分析。似然比检验显示，多等位基因、基因频率和不正确的疾病流行程度说明均有影响。
Significant features are described of a Monte Carlo simulation system. LINKERS, that generates nuclear family data conforming to one locus and two loci genetic models. Software engineering techniques help to produce a user friendly environment for studies of genetic ascertainment. LINKERS' 39 code modules are maintained and optimized using VAXset. Within a VAX/VMS workstation environment LINKERS generates a useful population of 10,000 families in 1 min. An example is presented to illustrate the use of LINKERS. Generated data were analysed using the segregation program POINTER. Likelihood ratio tests showed the effects of multiple alleles, gene frequency and incorrect specification of disease prevalence.