Hyperbaric oxygen: its mechanisms and efficacy.
Hyperbaric oxygen: its mechanisms and efficacy.
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DOI：
10.1097/prs.0b013e3181fbe2bf
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发表时间：
2011-01
影响因子：
3.6
通讯作者：
Thom SR
中科院分区：
文献类型：
--
作者：
Thom SR
本文概述了高压氧疗法 (HBO2) 的治疗机制，并回顾了其对整形外科和重建外科医生所见临床问题的疗效数据。本综述中的信息来自同行评审的医学文献。 HBO2 的主要机制是基于细胞内氧和氮活性物质的生成。反应性物质被认为在细胞信号转导级联中发挥核心作用，讨论将集中在这些途径上。系统评价和随机临床试验支持临床使用HBO2治疗难治性糖尿病伤口愈合和放射损伤；动物研究和少量临床试验支持对受损皮瓣和移植物以及缺血再灌注性疾病的治疗，但还需要进一步研究。临床和机械数据支持高压氧可用于治疗多种疾病。需要进一步的工作来阐明某些疾病的临床效用并完善患者选择标准以提高成本效益。
This paper outlines therapeutic mechanisms of hyperbaric oxygen therapy (HBO2) and reviews data on its efficacy for clinical problems seen by plastic and reconstructive surgeons. The information in this review was obtained from the peer-reviewed medical literature. Principal mechanisms of HBO2 are based on intracellular generation of reactive species of oxygen and nitrogen. Reactive species are recognized to play a central role in cell signal transduction cascades and the discussion will focus on these pathways. Systematic reviews and randomized clinical trials support clinical use of HBO2 for refractory diabetic wound healing and radiation injuries; treatment of compromised flaps and grafts and ischemia-reperfusion disorders is supported by animal studies and a small number of clinical trials, but further studies are warranted. Clinical and mechanistic data support use of hyperbaric oxygen for a variety of disorders. Further work is needed to clarify clinical utility for some disorders and to hone patient selection criteria to improve cost-efficacy.