APJ polymorphisms in coronary artery disease patients with and without hypertension
APJ polymorphisms in coronary artery disease patients with and without hypertension
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DOI：
10.3892/mmr.2011.685
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发表时间：
2012-02-01
影响因子：
3.4
通讯作者：
Pelissero, Gabriele
中科院分区：
文献类型：
--
作者：
Falcone, Colomba;Bozzini, Sara;Pelissero, Gabriele
爱帕琳是一种内源性肽，通过其All受体增加心脏变力性。某些发现表明，apelinergic系统可能在心血管疾病中具有病理生理作用，并且有证据表明apelinergic系统在体外和动物模型中在血压调节中的作用。apelin-APJ系统在心血管生理学中的作用及其与其他神经内分泌通路的相互作用尚未完全阐明。然而，少数报道的研究表明，apelin信号可能参与调节血压，心脏收缩功能，液体平衡，血管生成和抑制细胞凋亡。我们通过RFLP-PCR评估了意大利患者和健康对照者中G212 A和A445 CAll多态性与冠状动脉疾病（CAD）之间的可能关系。我们分析了664例患者（378例高血压患者）和143例对照者中All多态性的等位基因和基因型频率。两种多态性分析的患者与对照组之间的等位基因和基因型频率没有差异。在CAD人群中，高血压患者的G212等位基因频率高于非高血压患者。A445 C多态性在两个亚组中没有差异。虽然G212 A多态性的功能作用尚未确定，但可以假设A等位基因的存在可能导致apelin/APJ系统功能的增加，与高血压风险降低相关。
Apelin is an endogenous peptide that increases cardiac inotropism through its All receptor. Certain findings indicate that the apelinergic system may have a pathophysilogical role in cardiovascular disease and there is evidence showing the role of the apelinergic system in blood pressure regulation in vitro and in animal models. The role of the apelin-APJ system in cardiovascular physiology and its interaction with other neuroendocrine pathways has not been fully elucidated. However, the small number of reported studies indicates that apelin signaling may be involved in the regulation of blood pressure, cardiac contractile function, fluid balance, angiogenesis and inhibition of apoptosis. We evaluated the possible relationship between the G212A and A445C All polymorphisms and coronary artery disease (CAD) in Italian patients and in healthy controls by RFLP-PCR. We analyzed the allelic and genotypic frequencies of All polymorphisms in 664 patients (378 with hypertension) and 143 controls. There were no differences between allelic and genotypic frequencies in patients in respect to the controls for both polymorphisms analyzed. In the CAD population, there was an increased frequency of the G212 allele in patients with hypertension in respect to patients without hypertension. No differences were present in the two subgroups for the A445C polymorphism. Although the functional role of the G212A polymorphism has not yet been identified, it is possible to hypothesize that the presence of the A allele may cause a gain in function of the apelin/APJ system associated with a lower risk of hypertension.