The specific use of alginate from Laminaria japonica by Bacteroides species determined its modulation of the Bacteroides community
The specific use of alginate from Laminaria japonica by Bacteroides species determined its modulation of the Bacteroides community
复制标题
拟杆菌属物种对海带藻酸盐的具体利用决定了其对拟杆菌群落的调节作用
DOI：
10.1039/c9fo00289h
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发表时间：
2019-07-01
期刊：
影响因子：
6.1
通讯作者：
Song, Shuang
中科院分区：
文献类型：
--
作者：
Ai, Chunqing;Jiang, Pingrui;Song, Shuang
越来越多的研究表明，多糖的有益作用与肠道微生物群的改善密切相关，但多糖和肠道微生物群改变之间的联系机制尚不清楚。海带中的海藻酸盐（LJP-A）可以避免被上消化道消化并到达结肠，从而改善肠道微生物群落。 LJP-A 增加了一些拟杆菌科成员的相对丰度，例如拟杆菌属。肠道中拟杆菌属物种的分布对于个体而言是特定的，并且拟杆菌属物种对LJP-A的特定使用可以决定LJP-A诱导的肠道拟杆菌属群落的改变，其中在人类肠道微生物生态系统的拟杆菌属物种中发生基于碳源的互养相互作用。与其他物种相比，Bacteroides Finegoldii对LJP-A干预的反应更为积极，其特性可能与LJP-A的生物活性密切相关。这项研究为使用在特定个体体内最佳发酵的膳食多糖进行个性化治疗提供了理论依据。
Accumulating studies showed that the beneficial actions of polysaccharides were closely associated with an improvement of the gut microbiota, but mechanisms that link polysaccharides and gut microbiota alterations are ill defined. Alginate from Laminaria japonica (LJP-A) can avoid being digested by the upper digestive tract and reach the colon where it can improve the gut microbiota community. LJP-A increased the relative abundance of some Bacteroidaceae members, e.g. Bacteroides species. The distribution of Bacteroides species in the gut is specific to the individual, and the specific use of LJP-A by Bacteroides species can determine LJP-A-induced alterations of the intestinal Bacteroides community, in which carbon source-based syntrophic interactions occur in Bacteroides species of the human gut microbial ecosystem. Compared to other species, Bacteroides finegoldii responded more positively to LJP-A intervention, and its properties may have a close connection with the bioactivities of LJP-A. This study provides a rationale for personalized treatment with dietary polysaccharides that were optimally fermented within a particular individual.