Amphetamine-induced changes in behavior and caudate extracellular acetylcholine.
Amphetamine-induced changes in behavior and caudate extracellular acetylcholine.
复制标题
安非他明诱导的行为和尾状细胞外乙酰胆碱的变化。
DOI：
10.1016/0006-8993(92)90343-8
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发表时间：
1992
期刊：
影响因子：
2.9
通讯作者：
Segal,DS
中科院分区：
文献类型：
--
作者：
Florin,SM;Kuczenski,R;Segal,DS
使用体内微透析来研究安非他明对尾状细胞外乙酰胆碱的影响，并将这些影响与药物诱导的行为反应曲线进行比较。与抑制性多巴胺/乙酰胆碱相互作用一致，多巴胺受体激动剂阿扑吗啡降低乙酰胆碱浓度，而多巴胺受体拮抗剂氟哌啶醇增加乙酰胆碱浓度。相比之下，中等剂量的安非他明（1.75 mg/kg）并没有显着改变乙酰胆碱水平。此外，较高剂量的安非他明（5.0 mg/kg）促进乙酰胆碱水平增加两倍，并且这种增加与这些动物中口腔刻板印象的出现平行。这些结果表明，安非他明对尾状乙酰胆碱的影响可能与刻板行为的出现有关，但并不严格依赖于尾状多巴胺受体的激活。
In vivo microdialysis was used to study the effects of amphetamine on caudate extracellular acetylcholine and to compare these effects to the drug-induced behavioral response profile. Consistent with an inhibitory dopamine/acetylcholine interaction, the dopamine receptor agonist, apomorphine, decreased acetylcholine concentrations, while the dopamine receptor antagonist, haloperidol, increased acetylcholine. In contrast, an intermediate dose of amphetamine (1.75 mg/kg), did not significantly alter acetylcholine levels. Furthermore, a higher dose of amphetamine (5.0 mg/kg) promoted a two-fold increase in acetylcholine levels, and the increase paralleled the appearance of oral stereo-typies in these animals. These results suggest that the effects of amphetamine on caudate acetylcholine, which may be implicated in the appearance of stereotyped behaviors, are not strictly dependent on caudate dopamine receptor activation.