Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.
Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.
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DOI：
10.1016/j.nbd.2014.08.025
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发表时间：
2014-12
影响因子：
6.1
通讯作者：
Mahley, Robert W.
中科院分区：
文献类型：
--
作者：
Huang, Yadong;Mahley, Robert W.
载脂蛋白E是一种多功能蛋白质，在脂质代谢、神经生物学和神经退行性疾病中具有重要作用。它有三种主要的同种型（apoE 2、apoE 3和apoE 4），对脂质和神经元稳态具有不同的影响。apoE的主要功能是介导血浆或间质液中脂蛋白或脂质复合物与特定细胞表面受体的结合。这些受体内化含apoE的脂蛋白颗粒;因此，apoE参与脂质在身体的各种组织和细胞中的分布/再分布。此外，细胞内apoE可在生理学或病理生理学上调节各种细胞过程，包括细胞骨架组装和稳定性、线粒体完整性和功能以及树突形态和功能。阐明该蛋白质内的功能结构域和apoE主要亚型的三维结构，有助于我们在分子水平上了解其生理和病理生理作用。apoE具有多种细胞来源和多种结构和生物物理特性，可能广泛参与脂质代谢和神经生物学过程，可能通过各种途径与不同因子相互作用而涵盖神经元修复、重塑和变性的各种疾病。
Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism, neurobiology, and neurodegenerative diseases. It has three major isoforms (apoE2, apoE3, and apoE4) with different effects on lipid and neuronal homeostasis. A major function of apoE is to mediate the binding of lipoproteins or lipid complexes in the plasma or interstitial fluids to specific cell-surface receptors. These receptors internalize apoE-containing lipoprotein particles; thus, apoE participates in the distribution/redistribution of lipids among various tissues and cells of the body. In addition, intracellular apoE may modulate various cellular processes physiologically or pathophysiologically, including cytoskeletal assembly and stability, mitochondrial integrity and function, and dendritic morphology and function. Elucidation of the functional domains within this protein and of the three-dimensional structure of the major isoforms of apoE has contributed significantly to our understanding of its physiological and pathophysiological roles at a molecular level. It is likely that apoE, with its multiple cellular origins and multiple structural and biophysical properties, is involved widely in processes of lipid metabolism and neurobiology, possibly encompassing a variety of disorders of neuronal repair, remodeling, and degeneration by interacting with different factors through various pathways.
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DOI：
10.1523/jneurosci.0033-12.2012
发表时间：
2012-04-04
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bien-Ly N;Gillespie AK;Walker D;Yoon SY;Huang Y
通讯作者：
Huang Y
影响因子：
5.3
作者：
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影响因子：
4.8
作者：
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通讯作者：
Mahley, Robert W.
DOI：
10.1073/pnas.0812697106
发表时间：
2009-02-10
影响因子：
11.1
作者：
Agosta, Federica;Vossel, Keith A.;Gorno-Tempini, Maria Luisa
通讯作者：
Gorno-Tempini, Maria Luisa
影响因子：
34.7
作者：
Bu, Guojun
通讯作者：
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