High expression of L-type amino acid transporter 1 as a prognostic marker in bile duct adenocarcinomas.
High expression of L-type amino acid transporter 1 as a prognostic marker in bile duct adenocarcinomas.
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DOI：
10.1002/cam4.272
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发表时间：
2014-10
期刊：
影响因子：
4
通讯作者：
Murakumo, Yoshiki
中科院分区：
文献类型：
--
作者：
Yanagisawa, Nobuyuki;Hana, Kiyomi;Nakada, Norihiro;Ichinoe, Masaaki;Koizumi, Wasaburo;Endou, Hitoshi;Okayasu, Isao;Murakumo, Yoshiki
肿瘤细胞l型氨基酸转运蛋白（LAT） 1可能是一种预后指标和新的分子治疗药物的靶点。为了研究LAT1表达是否影响胆管癌患者的预后，我们在134例手术切除的胆管腺癌中检测了LAT1、LAT2、CD98和Ki-67的表达，其中包括84例远端肝外胆管腺癌、21例肝门胆管癌、15例肝内胆管癌和14例壶腹胆管腺癌。LAT1表达与CD98表达和Ki-67标记指数（LI）呈弱相关。Kaplan-Meier分析显示，lat1评分高和低的胆管腺癌患者预后有显著差异，而LAT2和CD98表达以及Ki-67 LI不能预测预后不良。lat1高/ lat2低评分患者预后较lat1低/ lat2高评分患者预后差（P = 0.0686）。多变量分析显示，LAT1表达、手术切缘、pT分期是独立的预后因素。综上所述，LAT1在胆管腺癌中的异常过表达预示着不良预后，提示LAT1可能是抗癌治疗的潜在靶点。
Oncocytic L-type amino acid transporter (LAT) 1 may be a prognostic indicator and target of new molecular therapeutic agents against malignancies. To investigate whether LAT1 expression influence the outcomes of patients with bile duct cancer, the expression of LAT1, LAT2, CD98, and Ki-67 was investigated immunohistochemically in 134 surgically resected bile duct adenocarcinomas, including 84 distal extrahepatic bile duct adenocarcinomas, 21 hilar cholangiocarcinomas, 15 intrahepatic cholangiocarcinomas, and 14 ampullary adenocarcinomas. LAT1 expression was weakly correlated with CD98 expression and Ki-67 labeling index (LI). Kaplan–Meier analysis showed a significant difference in prognosis between patients with bile duct adenocarcinomas having LAT1-high and -low scores, whereas LAT2 and CD98 expression and Ki-67 LI were not predictive of poor prognosis. Prognosis tended to be worse in patients having tumors with LAT1-high/LAT2-low than LAT1-low/LAT2-high scores (P = 0.0686). Multivariable analyses revealed that LAT1 expression, surgical margin, pT stage were independent prognostic factors. In conclusion, aberrant overexpression of LAT1 in bile duct adenocarcinoma predicts poor prognosis, suggesting that LAT1 may be a potential target of anticancer therapy.
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