What dermoscopy tells us about nevogenesis
What dermoscopy tells us about nevogenesis
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DOI：
10.1111/j.1346-8138.2010.01141.x
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发表时间：
2011-01-01
影响因子：
3.1
通讯作者：
Argenziano, Giuseppe
中科院分区：
文献类型：
--
作者：
Zalaudek, Iris;Catricala, Caterina;Argenziano, Giuseppe
痣的演变是一个复杂的过程，涉及多个宪法和环境因素。虽然组织病理学是诊断和分类黑色素细胞痣的金标准，广泛使用的体内诊断技术，如皮肤镜和最近的反射共聚焦显微镜，深刻地丰富了我们的知识，痣的形态变异在不同阶段的演变。此外，在我们对黑素细胞肿瘤形成中涉及的遗传改变和分子途径的理解方面也取得了重大进展。所有这些新获得的知识越来越多地质疑形态上不同的痣是否也是组织发生上不同的。在本文中，我们打算从已发表的有关黑素细胞肿瘤的临床和分子研究中提取一些要点，并试图将它们吸收到神经发生的综合概念中。
The evolution of nevi is a complex process involving several constitutional and environmental factors. Although histopathology is the gold standard for the diagnosis and classification of melanocytic nevi, the widespread use of in vivo diagnostic technologies such as dermoscopy and more recently of reflectance confocal microscopy, has enriched profoundly our knowledge regarding the morphological variability of nevi in different stages of their evolution. In addition, significant progress has been made in our understanding of genetic alterations and molecular pathways involved in the formation of melanocytic tumors. All this newly acquired knowledge increasingly questions whether morphologically different nevi are also histiogenetically different. In this article, we intend to extract some of the salient points from published clinical and molecular studies on melanocytic tumors and attempt to assimilate them into an integrative concept of nevogenesis.